Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study

• Main Authors: Jorde, Rolf, Grimnes, Guri
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2020
• Subjects: Biochemistry; Medicine; Cell Biology; Neuroscience; Biotechnology; 39999 Chemical Sciences not elsewhere classified; FOS Chemical sciences; Immunology; FOS Clinical medicine; 19999 Mathematical Sciences not elsewhere classified; FOS Mathematics; Cancer; Science Policy; 60506 Virology; FOS Biological sciences; Computational Biology; Tromsø
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.5193869; https://springernature.figshare.com/collections/Increased_calcium_intake_is_associated_lower_serum_25-hydroxyvitamin_D_levels_in_subjects_with_adequate_vitamin_D_intake_a_population-based_observational_study/5193869

Abstract Background There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. Method In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. Results There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (