Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ...
Abstract Background Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation. Methods We used individual data from 285,495 participants in four population-based cohor...
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ftdatacite:10.6084/m9.figshare.c.5024624 2024-04-28T08:32:24+00:00 Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... Amaral, André F. S. Imboden, Medea Wielscher, Matthias Rezwan, Faisal I. Minelli, Cosetta Garcia-Aymerich, Judith Peralta, Gabriela P. Auvinen, Juha Jeong, Ayoung Schaffner, Emmanuel Beckmeyer-Borowko, Anna Holloway, John W. Jarvelin, Marjo-Riitta Probst-Hensch, Nicole M. Jarvis, Deborah L. 2020 https://dx.doi.org/10.6084/m9.figshare.c.5024624 https://springernature.figshare.com/collections/Role_of_DNA_methylation_in_the_association_of_lung_function_with_body_mass_index_a_two-step_epigenetic_Mendelian_randomisation_study/5024624 unknown figshare Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Biochemistry Medicine Genetics FOS Biological sciences Molecular Biology Biotechnology Sociology FOS Sociology Cancer Science Policy Plant Biology Collection article 2020 ftdatacite https://doi.org/10.6084/m9.figshare.c.5024624 2024-04-02T12:00:32Z Abstract Background Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation. Methods We used individual data from 285,495 participants in four population-based cohorts: the European Community Respiratory Health Survey, the Northern Finland Birth Cohort 1966, the Swiss Study on Air Pollution and Lung Disease in Adults, and the UK Biobank. We carried out Mendelian randomisation (MR) analyses in two steps using a two-sample approach with SNPs as instrumental variables (IVs) in each step. In step 1 MR, we estimated the causal effect of BMI on peripheral blood DNA methylation (measured at genome-wide level) using 95 BMI-associated SNPs as IVs. In step 2 MR, we estimated the causal effect of DNA methylation on FEV1, FVC, and FEV1/FVC using two SNPs acting as methQTLs occurring close (in cis) to CpGs identified in the first step. These analyses were conducted after exclusion of weak ... Article in Journal/Newspaper Northern Finland DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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unknown |
topic |
Biochemistry Medicine Genetics FOS Biological sciences Molecular Biology Biotechnology Sociology FOS Sociology Cancer Science Policy Plant Biology |
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Biochemistry Medicine Genetics FOS Biological sciences Molecular Biology Biotechnology Sociology FOS Sociology Cancer Science Policy Plant Biology Amaral, André F. S. Imboden, Medea Wielscher, Matthias Rezwan, Faisal I. Minelli, Cosetta Garcia-Aymerich, Judith Peralta, Gabriela P. Auvinen, Juha Jeong, Ayoung Schaffner, Emmanuel Beckmeyer-Borowko, Anna Holloway, John W. Jarvelin, Marjo-Riitta Probst-Hensch, Nicole M. Jarvis, Deborah L. Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
topic_facet |
Biochemistry Medicine Genetics FOS Biological sciences Molecular Biology Biotechnology Sociology FOS Sociology Cancer Science Policy Plant Biology |
description |
Abstract Background Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation. Methods We used individual data from 285,495 participants in four population-based cohorts: the European Community Respiratory Health Survey, the Northern Finland Birth Cohort 1966, the Swiss Study on Air Pollution and Lung Disease in Adults, and the UK Biobank. We carried out Mendelian randomisation (MR) analyses in two steps using a two-sample approach with SNPs as instrumental variables (IVs) in each step. In step 1 MR, we estimated the causal effect of BMI on peripheral blood DNA methylation (measured at genome-wide level) using 95 BMI-associated SNPs as IVs. In step 2 MR, we estimated the causal effect of DNA methylation on FEV1, FVC, and FEV1/FVC using two SNPs acting as methQTLs occurring close (in cis) to CpGs identified in the first step. These analyses were conducted after exclusion of weak ... |
format |
Article in Journal/Newspaper |
author |
Amaral, André F. S. Imboden, Medea Wielscher, Matthias Rezwan, Faisal I. Minelli, Cosetta Garcia-Aymerich, Judith Peralta, Gabriela P. Auvinen, Juha Jeong, Ayoung Schaffner, Emmanuel Beckmeyer-Borowko, Anna Holloway, John W. Jarvelin, Marjo-Riitta Probst-Hensch, Nicole M. Jarvis, Deborah L. |
author_facet |
Amaral, André F. S. Imboden, Medea Wielscher, Matthias Rezwan, Faisal I. Minelli, Cosetta Garcia-Aymerich, Judith Peralta, Gabriela P. Auvinen, Juha Jeong, Ayoung Schaffner, Emmanuel Beckmeyer-Borowko, Anna Holloway, John W. Jarvelin, Marjo-Riitta Probst-Hensch, Nicole M. Jarvis, Deborah L. |
author_sort |
Amaral, André F. S. |
title |
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
title_short |
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
title_full |
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
title_fullStr |
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
title_full_unstemmed |
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study ... |
title_sort |
role of dna methylation in the association of lung function with body mass index: a two-step epigenetic mendelian randomisation study ... |
publisher |
figshare |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.5024624 https://springernature.figshare.com/collections/Role_of_DNA_methylation_in_the_association_of_lung_function_with_body_mass_index_a_two-step_epigenetic_Mendelian_randomisation_study/5024624 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.6084/m9.figshare.c.5024624 |
_version_ |
1797589608185200640 |