Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. Case presentation We...
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ftdatacite:10.6084/m9.figshare.c.4996043.v1 2023-05-15T17:07:47+02:00 Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany Buehler, Melanie Jesse, Sonja T. Kueck, Heike Lange, Bastian Koenig, Patricia Jo, Wendy K. Osterhaus, Albert Beineke, Andreas 2020 https://dx.doi.org/10.6084/m9.figshare.c.4996043.v1 https://springernature.figshare.com/collections/Lagovirus_europeus_GI_2_rabbit_hemorrhagic_disease_virus_2_infection_in_captive_mountain_hares_Lepus_timidus_in_Germany/4996043/1 unknown figshare https://dx.doi.org/10.1186/s12917-020-02386-4 https://dx.doi.org/10.6084/m9.figshare.c.4996043 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Microbiology FOS Biological sciences Genetics Molecular Biology Physiology Pharmacology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Cancer Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases Plant Biology 60506 Virology Computational Biology Collection article 2020 ftdatacite https://doi.org/10.6084/m9.figshare.c.4996043.v1 https://doi.org/10.1186/s12917-020-02386-4 https://doi.org/10.6084/m9.figshare.c.4996043 2021-11-05T12:55:41Z Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. Case presentation We describe the infection with a GI.2 strain, “Bremerhaven-17”, in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91–99%. Conclusion Our findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits. Article in Journal/Newspaper Lepus timidus DataCite Metadata Store (German National Library of Science and Technology) |
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collection |
DataCite Metadata Store (German National Library of Science and Technology) |
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language |
unknown |
topic |
Medicine Microbiology FOS Biological sciences Genetics Molecular Biology Physiology Pharmacology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Cancer Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases Plant Biology 60506 Virology Computational Biology |
spellingShingle |
Medicine Microbiology FOS Biological sciences Genetics Molecular Biology Physiology Pharmacology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Cancer Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases Plant Biology 60506 Virology Computational Biology Buehler, Melanie Jesse, Sonja T. Kueck, Heike Lange, Bastian Koenig, Patricia Jo, Wendy K. Osterhaus, Albert Beineke, Andreas Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
topic_facet |
Medicine Microbiology FOS Biological sciences Genetics Molecular Biology Physiology Pharmacology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Cancer Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases Plant Biology 60506 Virology Computational Biology |
description |
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. Case presentation We describe the infection with a GI.2 strain, “Bremerhaven-17”, in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91–99%. Conclusion Our findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits. |
format |
Article in Journal/Newspaper |
author |
Buehler, Melanie Jesse, Sonja T. Kueck, Heike Lange, Bastian Koenig, Patricia Jo, Wendy K. Osterhaus, Albert Beineke, Andreas |
author_facet |
Buehler, Melanie Jesse, Sonja T. Kueck, Heike Lange, Bastian Koenig, Patricia Jo, Wendy K. Osterhaus, Albert Beineke, Andreas |
author_sort |
Buehler, Melanie |
title |
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
title_short |
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
title_full |
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
title_fullStr |
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
title_full_unstemmed |
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany |
title_sort |
lagovirus europeus gi.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (lepus timidus) in germany |
publisher |
figshare |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4996043.v1 https://springernature.figshare.com/collections/Lagovirus_europeus_GI_2_rabbit_hemorrhagic_disease_virus_2_infection_in_captive_mountain_hares_Lepus_timidus_in_Germany/4996043/1 |
genre |
Lepus timidus |
genre_facet |
Lepus timidus |
op_relation |
https://dx.doi.org/10.1186/s12917-020-02386-4 https://dx.doi.org/10.6084/m9.figshare.c.4996043 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4996043.v1 https://doi.org/10.1186/s12917-020-02386-4 https://doi.org/10.6084/m9.figshare.c.4996043 |
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