Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway
Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those wi...
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.4985381 https://springernature.figshare.com/collections/Pharmacological_management_of_modifiable_cardiovascular_risk_factors_blood_pressure_and_lipids_following_diagnosis_of_myocardial_infarction_stroke_and_diabetes_comparison_between_population-based_studies_in_Russia_and_Norway/4985381 |
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ftdatacite:10.6084/m9.figshare.c.4985381 2023-05-15T18:34:18+02:00 Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. 2020 https://dx.doi.org/10.6084/m9.figshare.c.4985381 https://springernature.figshare.com/collections/Pharmacological_management_of_modifiable_cardiovascular_risk_factors_blood_pressure_and_lipids_following_diagnosis_of_myocardial_infarction_stroke_and_diabetes_comparison_between_population-based_studies_in_Russia_and_Norway/4985381 unknown figshare https://dx.doi.org/10.1186/s12872-020-01513-1 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Pharmacology Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Science Policy Collection article 2020 ftdatacite https://doi.org/10.6084/m9.figshare.c.4985381 https://doi.org/10.1186/s12872-020-01513-1 2021-11-05T12:55:41Z Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes. Methods The study population was adults aged 40–69 years reporting a diagnosis of myocardial infarction (MI), stroke and/or diabetes participating in cross-sectional population-based studies in Russia (Know Your Heart (KYH) 2015–18 N = 626) and Norway (The Tromsø Study 2015–16 (Tromsø 7) N = 1353). Reported medications were coded according to the 2016 WHO Anatomical Therapeutic Chemical Classification system. Treatment targets were defined using the Joint European Societies guidelines for CVD prevention in clinical practice (2016). Results Age- and sex-standardized prevalence of use of lipid-lowering medications was higher in Tromsø 7 for all three conditions with a disproportionately large difference in those reporting MI (+ 48% (95% CI 39, 57%)). Proportion meeting treatment targets for LDL cholesterol was poor in both studies (age- and sex-standardized prevalence of control KYH vs Tromsø 7: MI 5.1% vs 10.1%; stroke 11.6% vs 5.8%; diabetes 24.9% vs 23.3%). Use of antihypertensive medication was higher in KYH for stroke (+ 40% (95% CI 30, 50%)) and diabetes (+ 27% (95% CI 19, 34%)) groups but approximately equal for the MI group (− 1% (95% CI -1, 1%)). Proportion meeting blood pressure targets was lower in KYH vs Tromsø 7 (MI 51.8% vs 76.3%; stroke 49.5% vs 69.6%; diabetes 51.9% vs 63.9%). Conclusions We identified different patterns of medication use in people with CVD and diabetes. However despite higher use of lipid-lowering medication in the Norwegian study treatment to target for total cholesterol was poor in both Russian and Norwegian studies. In contrast we found higher levels of use of antihypertensive medications in the Russian study but also that less participants met treatment targets for blood pressure. Further work should investigate what factors are responsible for this seeming paradox and how management of modifiable risk factors for secondary prevention could be improved. Article in Journal/Newspaper Tromsø DataCite Metadata Store (German National Library of Science and Technology) Norway Tromsø |
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DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine Pharmacology Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Science Policy |
spellingShingle |
Medicine Pharmacology Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Science Policy Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
topic_facet |
Medicine Pharmacology Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Science Policy |
description |
Abstract Background Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes. Methods The study population was adults aged 40–69 years reporting a diagnosis of myocardial infarction (MI), stroke and/or diabetes participating in cross-sectional population-based studies in Russia (Know Your Heart (KYH) 2015–18 N = 626) and Norway (The Tromsø Study 2015–16 (Tromsø 7) N = 1353). Reported medications were coded according to the 2016 WHO Anatomical Therapeutic Chemical Classification system. Treatment targets were defined using the Joint European Societies guidelines for CVD prevention in clinical practice (2016). Results Age- and sex-standardized prevalence of use of lipid-lowering medications was higher in Tromsø 7 for all three conditions with a disproportionately large difference in those reporting MI (+ 48% (95% CI 39, 57%)). Proportion meeting treatment targets for LDL cholesterol was poor in both studies (age- and sex-standardized prevalence of control KYH vs Tromsø 7: MI 5.1% vs 10.1%; stroke 11.6% vs 5.8%; diabetes 24.9% vs 23.3%). Use of antihypertensive medication was higher in KYH for stroke (+ 40% (95% CI 30, 50%)) and diabetes (+ 27% (95% CI 19, 34%)) groups but approximately equal for the MI group (− 1% (95% CI -1, 1%)). Proportion meeting blood pressure targets was lower in KYH vs Tromsø 7 (MI 51.8% vs 76.3%; stroke 49.5% vs 69.6%; diabetes 51.9% vs 63.9%). Conclusions We identified different patterns of medication use in people with CVD and diabetes. However despite higher use of lipid-lowering medication in the Norwegian study treatment to target for total cholesterol was poor in both Russian and Norwegian studies. In contrast we found higher levels of use of antihypertensive medications in the Russian study but also that less participants met treatment targets for blood pressure. Further work should investigate what factors are responsible for this seeming paradox and how management of modifiable risk factors for secondary prevention could be improved. |
format |
Article in Journal/Newspaper |
author |
Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. |
author_facet |
Cook, Sarah Hopstock, Laila A. Eggen, Anne Elise Bates, Katie Iakunchykova, Olena Kontsevaya, Anna McKee, Martin Schirmer, Henrik Voevoda, Michael Kudryavtsev, Alexander V. Malyutina, Sofia Leon, David A. |
author_sort |
Cook, Sarah |
title |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_short |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_full |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_fullStr |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_full_unstemmed |
Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway |
title_sort |
pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in russia and norway |
publisher |
figshare |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4985381 https://springernature.figshare.com/collections/Pharmacological_management_of_modifiable_cardiovascular_risk_factors_blood_pressure_and_lipids_following_diagnosis_of_myocardial_infarction_stroke_and_diabetes_comparison_between_population-based_studies_in_Russia_and_Norway/4985381 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://dx.doi.org/10.1186/s12872-020-01513-1 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4985381 https://doi.org/10.1186/s12872-020-01513-1 |
_version_ |
1766218984417394688 |