Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore
Abstract Background Different population trajectories are expected to impact the signature of neutral and adaptive processes at multiple levels, challenging the assessment of the relative roles of different microevolutionary forces. Here, we integrate adaptive and neutral variability patterns to dis...
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ftdatacite:10.6084/m9.figshare.c.4468511 2023-05-15T15:51:04+02:00 Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore Rocha, Rita MagalhĂŁes, Vanessa JosĂŠ LĂłpez-Bao Loo, Wessel Llaneza, Luis Alvares, Francisco Esteves, Pedro Godinho, Raquel 2019 https://dx.doi.org/10.6084/m9.figshare.c.4468511 https://springernature.figshare.com/collections/Alternated_selection_mechanisms_maintain_adaptive_diversity_in_different_demographic_scenarios_of_a_large_carnivore/4468511 unknown Figshare https://dx.doi.org/10.1186/s12862-019-1420-5 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Microbiology FOS Biological sciences Cell Biology Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Marine Biology Cancer Inorganic Chemistry FOS Chemical sciences Collection article 2019 ftdatacite https://doi.org/10.6084/m9.figshare.c.4468511 https://doi.org/10.1186/s12862-019-1420-5 2021-11-05T12:55:41Z Abstract Background Different population trajectories are expected to impact the signature of neutral and adaptive processes at multiple levels, challenging the assessment of the relative roles of different microevolutionary forces. Here, we integrate adaptive and neutral variability patterns to disentangle how adaptive diversity is driven under different demographic scenarios within the Iberian wolf (Canis lupus) range. We studied the persistent, the expanding and a small, isolated group within the Iberian wolf population, using 3 MHC class II genes (DRB1, DQA1, and DQB1), which diversity was compared with 39 microsatellite loci. Results Both the persistent and the expanding groups show evidence of balancing selection, revealed by a significant departure from neutrality at MHC loci, significant higher observed and expected heterozygosity and lower differentiation at MHC than at neutral loci, and signs of positive selection. However, despite exhibiting a significantly higher genetic diversity than the isolated group, the persistent group did not show significant excess of MHC heterozygotes. The expanding group, while showing a similar level of genetic diversity than the persistent group, displays by contrast a significant excess of MHC heterozygotes, which is compatible with the heterozygote advantage mechanism. Results are not clear regarding the role of drift and selection in the isolated group due to the small size of this population. Although diversity indices of MHC loci correspond to neutral expectations in the isolated group, accelerated MHC divergence, revealed by a higher differentiation at MHC than neutral loci, may indicate diversifying selection. Conclusion Different selective pressures were observed in the three different demographic scenarios, which are possibly driven by different selection mechanisms to maintain adaptive diversity. Article in Journal/Newspaper Canis lupus DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Microbiology FOS Biological sciences Cell Biology Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Marine Biology Cancer Inorganic Chemistry FOS Chemical sciences |
spellingShingle |
Microbiology FOS Biological sciences Cell Biology Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Marine Biology Cancer Inorganic Chemistry FOS Chemical sciences Rocha, Rita MagalhĂŁes, Vanessa JosĂŠ LĂłpez-Bao Loo, Wessel Llaneza, Luis Alvares, Francisco Esteves, Pedro Godinho, Raquel Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
topic_facet |
Microbiology FOS Biological sciences Cell Biology Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Marine Biology Cancer Inorganic Chemistry FOS Chemical sciences |
description |
Abstract Background Different population trajectories are expected to impact the signature of neutral and adaptive processes at multiple levels, challenging the assessment of the relative roles of different microevolutionary forces. Here, we integrate adaptive and neutral variability patterns to disentangle how adaptive diversity is driven under different demographic scenarios within the Iberian wolf (Canis lupus) range. We studied the persistent, the expanding and a small, isolated group within the Iberian wolf population, using 3 MHC class II genes (DRB1, DQA1, and DQB1), which diversity was compared with 39 microsatellite loci. Results Both the persistent and the expanding groups show evidence of balancing selection, revealed by a significant departure from neutrality at MHC loci, significant higher observed and expected heterozygosity and lower differentiation at MHC than at neutral loci, and signs of positive selection. However, despite exhibiting a significantly higher genetic diversity than the isolated group, the persistent group did not show significant excess of MHC heterozygotes. The expanding group, while showing a similar level of genetic diversity than the persistent group, displays by contrast a significant excess of MHC heterozygotes, which is compatible with the heterozygote advantage mechanism. Results are not clear regarding the role of drift and selection in the isolated group due to the small size of this population. Although diversity indices of MHC loci correspond to neutral expectations in the isolated group, accelerated MHC divergence, revealed by a higher differentiation at MHC than neutral loci, may indicate diversifying selection. Conclusion Different selective pressures were observed in the three different demographic scenarios, which are possibly driven by different selection mechanisms to maintain adaptive diversity. |
format |
Article in Journal/Newspaper |
author |
Rocha, Rita MagalhĂŁes, Vanessa JosĂŠ LĂłpez-Bao Loo, Wessel Llaneza, Luis Alvares, Francisco Esteves, Pedro Godinho, Raquel |
author_facet |
Rocha, Rita MagalhĂŁes, Vanessa JosĂŠ LĂłpez-Bao Loo, Wessel Llaneza, Luis Alvares, Francisco Esteves, Pedro Godinho, Raquel |
author_sort |
Rocha, Rita |
title |
Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
title_short |
Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
title_full |
Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
title_fullStr |
Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
title_full_unstemmed |
Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
title_sort |
alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore |
publisher |
Figshare |
publishDate |
2019 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4468511 https://springernature.figshare.com/collections/Alternated_selection_mechanisms_maintain_adaptive_diversity_in_different_demographic_scenarios_of_a_large_carnivore/4468511 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
https://dx.doi.org/10.1186/s12862-019-1420-5 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4468511 https://doi.org/10.1186/s12862-019-1420-5 |
_version_ |
1766386131403800576 |