Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population
Abstract Background Heart rate variability (HRV) and baroreflex sensitivity (BRS) measurements provide means for the objective assessment of cardiovascular autonomic function. As previous studies have associated chronic pain with abnormal autonomic function, we aimed to characterize the relationship...
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ftdatacite:10.6084/m9.figshare.c.4386101.v1 2023-05-15T17:42:55+02:00 Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population Oura, Petteri Hautala, Arto Kiviniemi, Antti Auvinen, Juha Puukka, Katri Tulppo, Mikko Huikuri, Heikki Seppänen, Tapio Karppinen, Jaro 2019 https://dx.doi.org/10.6084/m9.figshare.c.4386101.v1 https://springernature.figshare.com/collections/Musculoskeletal_pains_and_cardiovascular_autonomic_function_in_the_general_Northern_Finnish_population/4386101/1 unknown Figshare https://dx.doi.org/10.1186/s12891-019-2426-2 https://dx.doi.org/10.6084/m9.figshare.c.4386101 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Genetics FOS Biological sciences Neuroscience Physiology 69999 Biological Sciences not elsewhere classified Cancer Science Policy 110309 Infectious Diseases FOS Health sciences Collection article 2019 ftdatacite https://doi.org/10.6084/m9.figshare.c.4386101.v1 https://doi.org/10.1186/s12891-019-2426-2 https://doi.org/10.6084/m9.figshare.c.4386101 2021-11-05T12:55:41Z Abstract Background Heart rate variability (HRV) and baroreflex sensitivity (BRS) measurements provide means for the objective assessment of cardiovascular autonomic function. As previous studies have associated chronic pain with abnormal autonomic function, we aimed to characterize the relationship between the number of musculoskeletal pain sites (NPS), pain intensity, and cardiovascular autonomic function among the population-based Northern Finland Birth Cohort 1966. Methods At the age of 46, cohort members self-reported their musculoskeletal pains (enabling the determination of NPS [0–8] and pain intensity [Numerical Rating Scale, NRS, 0–10]) and underwent clinical assessments of cardiovascular autonomic function in seated and standing positions (HRV variables: heart rate [HR] and root mean square of successive differences in beat-to-beat intervals [rMSSD] for the entire cohort; BRS variables: low-frequency systolic blood pressure variability [SBPV] and cross-spectral baroreflex sensitivity [BRS] for those attending the examination in Oulu, Finland). Extensive confounder data were also collected (body mass index, physical activity, smoking, Hopkins Symptom Checklist-25, comorbidities, and medications). The full samples included 4186 and 2031 individuals (HRV and BRS samples, respectively). Three subanalyses focused on individuals with intense and frequent pain, individuals with symptoms of depression and anxiety, and the relationship between pain intensity and autonomic parameters. Results Linear regression models showed varying associations between NPS, pain intensity, and cardiovascular autonomic parameters. However, after all adjustments NPS was only associated with one outcome among women (BRS, standing: beta = − 0.015, p = 0.048) and two among men (HR, seated: beta = − 0.902, p = 0.003; HR, standing: beta = − 0.843, p = 0.014). Pain intensity was not associated with any outcome after full adjustments. Significant sex*pain interactions were found in the data. Conclusions Our data suggest that musculoskeletal pain has, at most, a limited independent association with cardiovascular autonomic function. Future studies should carefully account for the potential confounders and sex interactions that this study revealed. Article in Journal/Newspaper Northern Finland DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine Genetics FOS Biological sciences Neuroscience Physiology 69999 Biological Sciences not elsewhere classified Cancer Science Policy 110309 Infectious Diseases FOS Health sciences |
spellingShingle |
Medicine Genetics FOS Biological sciences Neuroscience Physiology 69999 Biological Sciences not elsewhere classified Cancer Science Policy 110309 Infectious Diseases FOS Health sciences Oura, Petteri Hautala, Arto Kiviniemi, Antti Auvinen, Juha Puukka, Katri Tulppo, Mikko Huikuri, Heikki Seppänen, Tapio Karppinen, Jaro Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
topic_facet |
Medicine Genetics FOS Biological sciences Neuroscience Physiology 69999 Biological Sciences not elsewhere classified Cancer Science Policy 110309 Infectious Diseases FOS Health sciences |
description |
Abstract Background Heart rate variability (HRV) and baroreflex sensitivity (BRS) measurements provide means for the objective assessment of cardiovascular autonomic function. As previous studies have associated chronic pain with abnormal autonomic function, we aimed to characterize the relationship between the number of musculoskeletal pain sites (NPS), pain intensity, and cardiovascular autonomic function among the population-based Northern Finland Birth Cohort 1966. Methods At the age of 46, cohort members self-reported their musculoskeletal pains (enabling the determination of NPS [0–8] and pain intensity [Numerical Rating Scale, NRS, 0–10]) and underwent clinical assessments of cardiovascular autonomic function in seated and standing positions (HRV variables: heart rate [HR] and root mean square of successive differences in beat-to-beat intervals [rMSSD] for the entire cohort; BRS variables: low-frequency systolic blood pressure variability [SBPV] and cross-spectral baroreflex sensitivity [BRS] for those attending the examination in Oulu, Finland). Extensive confounder data were also collected (body mass index, physical activity, smoking, Hopkins Symptom Checklist-25, comorbidities, and medications). The full samples included 4186 and 2031 individuals (HRV and BRS samples, respectively). Three subanalyses focused on individuals with intense and frequent pain, individuals with symptoms of depression and anxiety, and the relationship between pain intensity and autonomic parameters. Results Linear regression models showed varying associations between NPS, pain intensity, and cardiovascular autonomic parameters. However, after all adjustments NPS was only associated with one outcome among women (BRS, standing: beta = − 0.015, p = 0.048) and two among men (HR, seated: beta = − 0.902, p = 0.003; HR, standing: beta = − 0.843, p = 0.014). Pain intensity was not associated with any outcome after full adjustments. Significant sex*pain interactions were found in the data. Conclusions Our data suggest that musculoskeletal pain has, at most, a limited independent association with cardiovascular autonomic function. Future studies should carefully account for the potential confounders and sex interactions that this study revealed. |
format |
Article in Journal/Newspaper |
author |
Oura, Petteri Hautala, Arto Kiviniemi, Antti Auvinen, Juha Puukka, Katri Tulppo, Mikko Huikuri, Heikki Seppänen, Tapio Karppinen, Jaro |
author_facet |
Oura, Petteri Hautala, Arto Kiviniemi, Antti Auvinen, Juha Puukka, Katri Tulppo, Mikko Huikuri, Heikki Seppänen, Tapio Karppinen, Jaro |
author_sort |
Oura, Petteri |
title |
Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
title_short |
Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
title_full |
Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
title_fullStr |
Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
title_full_unstemmed |
Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population |
title_sort |
musculoskeletal pains and cardiovascular autonomic function in the general northern finnish population |
publisher |
Figshare |
publishDate |
2019 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4386101.v1 https://springernature.figshare.com/collections/Musculoskeletal_pains_and_cardiovascular_autonomic_function_in_the_general_Northern_Finnish_population/4386101/1 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://dx.doi.org/10.1186/s12891-019-2426-2 https://dx.doi.org/10.6084/m9.figshare.c.4386101 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4386101.v1 https://doi.org/10.1186/s12891-019-2426-2 https://doi.org/10.6084/m9.figshare.c.4386101 |
_version_ |
1766144843097047040 |