Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates ...

• Main Authors: Lopes-Marques, Mónica, Kabeya, Naoki, Qian, Yu, Ruivo, Raquel, Santos, Miguel, Venkatesh, Byrappa, Tocher, Douglas, Castro, L., Monroig, Óscar
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2018
• Subjects: Biochemistry; Medicine; Cell Biology; Genetics; FOS Biological sciences; Evolutionary Biology; Environmental Sciences not elsewhere classified; Ecology; Sociology; FOS Sociology; Marine Biology; Inorganic Chemistry; FOS Chemical sciences; Infectious Diseases; FOS Health sciences; Arctic
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.4273382; https://springernature.figshare.com/collections/Retention_of_fatty_acyl_desaturase_1_fads1_in_Elopomorpha_and_Cyclostomata_provides_novel_insights_into_the_evolution_of_long-chain_polyunsaturated_fatty_acid_biosynthesis_in_vertebrates/4273382

Abstract Background Provision of long-chain polyunsaturated fatty acids (LC-PUFA) in vertebrates occurs through the diet or via endogenous production from C18 precursors through consecutive elongations and desaturations. It has been postulated that the abundance of LC-PUFA in the marine environment has remarkably modulated the gene complement and function of Fads in marine teleosts. In vertebrates two fatty acyl desaturases, namely Fads1 and Fads2, encode ∆5 and ∆6 desaturases, respectively. To fully clarify the evolutionary history of LC-PUFA biosynthesis in vertebrates, we investigated the gene repertoire and function of Fads from species placed at key evolutionary nodes. Results We demonstrate that functional Fads1Δ5 and Fads2∆6 arose from a tandem gene duplication in the ancestor of vertebrates, since they are present in the Arctic lamprey. Additionally, we show that a similar condition was retained in ray-finned fish such as the Senegal bichir and spotted gar, with the identification of fads1 genes in ...