Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden
Abstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite cou...
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ftdatacite:10.6084/m9.figshare.c.4217444.v1 2023-05-15T17:44:50+02:00 Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden Lilja, Mikael Widerström, Micael Lindh, Johan 2018 https://dx.doi.org/10.6084/m9.figshare.c.4217444.v1 https://figshare.com/collections/Persisting_post-infection_symptoms_2_years_after_a_large_waterborne_outbreak_of_Cryptosporidium_hominis_in_northern_Sweden/4217444/1 unknown Figshare https://dx.doi.org/10.1186/s13104-018-3721-y https://dx.doi.org/10.6084/m9.figshare.c.4217444 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Biotechnology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy 60506 Virology Computational Biology Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.4217444.v1 https://doi.org/10.1186/s13104-018-3721-y https://doi.org/10.6084/m9.figshare.c.4217444 2021-11-05T12:55:41Z Abstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite could cause sequelae in infected individuals up to 28 months after the outbreak. We compared cases linked to the outbreak and the previous follow-up study with non-cases regarding symptoms present up to 28 months after the initial infection. We investigated whether cases were more likely to report a list of symptoms at follow-up compared to non-cases, calculating odds ratio and 95% confidence interval obtained through logistic regression. Results A total of 559 individuals (215 cases) were included in the study. Forty-eight percent of the outbreak cases reported symptoms at follow-up. Compared to non-cases, cases were more likely to report watery diarrhea, diarrhea, abdominal pain, fatigue, nausea, headache, or joint stiffness/pain/discomfort at follow-up after adjusting for age and sex. Our findings suggest that gastrointestinal symptoms and joint pain can persist several years after the initial Cryptosporidium infection and should be regarded as a potential cause of unexplained gastrointestinal symptoms or joint pain in people who have had this infection. Article in Journal/Newspaper Northern Sweden DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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language |
unknown |
topic |
Medicine Biotechnology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy 60506 Virology Computational Biology |
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Medicine Biotechnology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy 60506 Virology Computational Biology Lilja, Mikael Widerström, Micael Lindh, Johan Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
topic_facet |
Medicine Biotechnology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy 60506 Virology Computational Biology |
description |
Abstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite could cause sequelae in infected individuals up to 28 months after the outbreak. We compared cases linked to the outbreak and the previous follow-up study with non-cases regarding symptoms present up to 28 months after the initial infection. We investigated whether cases were more likely to report a list of symptoms at follow-up compared to non-cases, calculating odds ratio and 95% confidence interval obtained through logistic regression. Results A total of 559 individuals (215 cases) were included in the study. Forty-eight percent of the outbreak cases reported symptoms at follow-up. Compared to non-cases, cases were more likely to report watery diarrhea, diarrhea, abdominal pain, fatigue, nausea, headache, or joint stiffness/pain/discomfort at follow-up after adjusting for age and sex. Our findings suggest that gastrointestinal symptoms and joint pain can persist several years after the initial Cryptosporidium infection and should be regarded as a potential cause of unexplained gastrointestinal symptoms or joint pain in people who have had this infection. |
format |
Article in Journal/Newspaper |
author |
Lilja, Mikael Widerström, Micael Lindh, Johan |
author_facet |
Lilja, Mikael Widerström, Micael Lindh, Johan |
author_sort |
Lilja, Mikael |
title |
Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
title_short |
Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
title_full |
Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
title_fullStr |
Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
title_full_unstemmed |
Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
title_sort |
persisting post-infection symptoms 2 years after a large waterborne outbreak of cryptosporidium hominis in northern sweden |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4217444.v1 https://figshare.com/collections/Persisting_post-infection_symptoms_2_years_after_a_large_waterborne_outbreak_of_Cryptosporidium_hominis_in_northern_Sweden/4217444/1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://dx.doi.org/10.1186/s13104-018-3721-y https://dx.doi.org/10.6084/m9.figshare.c.4217444 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4217444.v1 https://doi.org/10.1186/s13104-018-3721-y https://doi.org/10.6084/m9.figshare.c.4217444 |
_version_ |
1766147120437395456 |