The genomic impact of historical hybridization with massive mitochondrial DNA introgression
Abstract Background The extent to which selection determines interspecific patterns of genetic exchange enlightens the role of adaptation in evolution and speciation. Often reported extensive interspecific introgression could be selection-driven, but also result from demographic processes, especiall...
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ftdatacite:10.6084/m9.figshare.c.4181486.v1 2023-05-15T15:11:46+02:00 The genomic impact of historical hybridization with massive mitochondrial DNA introgression Seixas, Fernando Boursot, Pierre JosÊ Melo-Ferreira 2018 https://dx.doi.org/10.6084/m9.figshare.c.4181486.v1 https://figshare.com/collections/The_genomic_impact_of_historical_hybridization_with_massive_mitochondrial_DNA_introgression/4181486/1 unknown Figshare https://dx.doi.org/10.1186/s13059-018-1471-8 https://dx.doi.org/10.6084/m9.figshare.c.4181486 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Cell Biology Genetics FOS Biological sciences Evolutionary Biology Ecology Marine Biology Inorganic Chemistry FOS Chemical sciences Plant Biology Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.4181486.v1 https://doi.org/10.1186/s13059-018-1471-8 https://doi.org/10.6084/m9.figshare.c.4181486 2021-11-05T12:55:41Z Abstract Background The extent to which selection determines interspecific patterns of genetic exchange enlightens the role of adaptation in evolution and speciation. Often reported extensive interspecific introgression could be selection-driven, but also result from demographic processes, especially in cases of invasive species replacements, which can promote introgression at their invasion front. Because invasion and selective sweeps similarly mold variation, population genetics evidence for selection can only be gathered in an explicit demographic framework. The Iberian hare, Lepus granatensis, displays in its northern range extensive mitochondrial DNA introgression from L. timidus, an arctic/boreal species that it replaced locally after the last glacial maximum. We use whole-genome sequencing to infer geographic and genomic patterns of nuclear introgression and fit a neutral model of species replacement with hybridization, allowing us to evaluate how selection influenced introgression genome-wide, including for mtDNA. Results Although the average nuclear and mtDNA introgression patterns contrast strongly, they fit a single demographic model of post-glacial invasive replacement of timidus by granatensis. Outliers of elevated introgression include several genes related to immunity, spermatogenesis, and mitochondrial metabolism. Introgression is reduced on the X chromosome and in low recombining regions. Conclusions General nuclear and mtDNA patterns of introgression can be explained by purely demographic processes. Hybrid incompatibilities and interplay between selection and recombination locally modulate levels of nuclear introgression. Selection promoted introgression of some genes involved in conflicts, either interspecific (parasites) or possibly cytonuclear. In the latter case, nuclear introgression could mitigate the potential negative effects of alien mtDNA on mitochondrial metabolism and male-specific traits. Article in Journal/Newspaper Arctic DataCite Metadata Store (German National Library of Science and Technology) Arctic |
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DataCite Metadata Store (German National Library of Science and Technology) |
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unknown |
topic |
Cell Biology Genetics FOS Biological sciences Evolutionary Biology Ecology Marine Biology Inorganic Chemistry FOS Chemical sciences Plant Biology |
spellingShingle |
Cell Biology Genetics FOS Biological sciences Evolutionary Biology Ecology Marine Biology Inorganic Chemistry FOS Chemical sciences Plant Biology Seixas, Fernando Boursot, Pierre JosĂŠ Melo-Ferreira The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
topic_facet |
Cell Biology Genetics FOS Biological sciences Evolutionary Biology Ecology Marine Biology Inorganic Chemistry FOS Chemical sciences Plant Biology |
description |
Abstract Background The extent to which selection determines interspecific patterns of genetic exchange enlightens the role of adaptation in evolution and speciation. Often reported extensive interspecific introgression could be selection-driven, but also result from demographic processes, especially in cases of invasive species replacements, which can promote introgression at their invasion front. Because invasion and selective sweeps similarly mold variation, population genetics evidence for selection can only be gathered in an explicit demographic framework. The Iberian hare, Lepus granatensis, displays in its northern range extensive mitochondrial DNA introgression from L. timidus, an arctic/boreal species that it replaced locally after the last glacial maximum. We use whole-genome sequencing to infer geographic and genomic patterns of nuclear introgression and fit a neutral model of species replacement with hybridization, allowing us to evaluate how selection influenced introgression genome-wide, including for mtDNA. Results Although the average nuclear and mtDNA introgression patterns contrast strongly, they fit a single demographic model of post-glacial invasive replacement of timidus by granatensis. Outliers of elevated introgression include several genes related to immunity, spermatogenesis, and mitochondrial metabolism. Introgression is reduced on the X chromosome and in low recombining regions. Conclusions General nuclear and mtDNA patterns of introgression can be explained by purely demographic processes. Hybrid incompatibilities and interplay between selection and recombination locally modulate levels of nuclear introgression. Selection promoted introgression of some genes involved in conflicts, either interspecific (parasites) or possibly cytonuclear. In the latter case, nuclear introgression could mitigate the potential negative effects of alien mtDNA on mitochondrial metabolism and male-specific traits. |
format |
Article in Journal/Newspaper |
author |
Seixas, Fernando Boursot, Pierre JosĂŠ Melo-Ferreira |
author_facet |
Seixas, Fernando Boursot, Pierre JosĂŠ Melo-Ferreira |
author_sort |
Seixas, Fernando |
title |
The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
title_short |
The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
title_full |
The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
title_fullStr |
The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
title_full_unstemmed |
The genomic impact of historical hybridization with massive mitochondrial DNA introgression |
title_sort |
genomic impact of historical hybridization with massive mitochondrial dna introgression |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4181486.v1 https://figshare.com/collections/The_genomic_impact_of_historical_hybridization_with_massive_mitochondrial_DNA_introgression/4181486/1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
https://dx.doi.org/10.1186/s13059-018-1471-8 https://dx.doi.org/10.6084/m9.figshare.c.4181486 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4181486.v1 https://doi.org/10.1186/s13059-018-1471-8 https://doi.org/10.6084/m9.figshare.c.4181486 |
_version_ |
1766342571450171392 |