Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm"
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we docu...
Main Authors: | , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
Figshare
2018
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.4100837.v1 https://figshare.com/collections/Supplementary_material_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm_/4100837/1 |
id |
ftdatacite:10.6084/m9.figshare.c.4100837.v1 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.c.4100837.v1 2023-05-15T15:59:38+02:00 Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" Gianasi, Bruno L. Jean-François Hamel Mercier, Annie 2018 https://dx.doi.org/10.6084/m9.figshare.c.4100837.v1 https://figshare.com/collections/Supplementary_material_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm_/4100837/1 unknown Figshare https://dx.doi.org/10.1098/rspb.2018.0339 https://dx.doi.org/10.6084/m9.figshare.c.4100837 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Ecology FOS Biological sciences Developmental Biology 60801 Animal Behaviour Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.4100837.v1 https://doi.org/10.1098/rspb.2018.0339 https://doi.org/10.6084/m9.figshare.c.4100837 2021-11-05T12:55:41Z Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we documented for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. Article in Journal/Newspaper Cucumaria frondosa DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Ecology FOS Biological sciences Developmental Biology 60801 Animal Behaviour |
spellingShingle |
Ecology FOS Biological sciences Developmental Biology 60801 Animal Behaviour Gianasi, Bruno L. Jean-François Hamel Mercier, Annie Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
topic_facet |
Ecology FOS Biological sciences Developmental Biology 60801 Animal Behaviour |
description |
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we documented for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. |
format |
Article in Journal/Newspaper |
author |
Gianasi, Bruno L. Jean-François Hamel Mercier, Annie |
author_facet |
Gianasi, Bruno L. Jean-François Hamel Mercier, Annie |
author_sort |
Gianasi, Bruno L. |
title |
Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
title_short |
Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
title_full |
Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
title_fullStr |
Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
title_full_unstemmed |
Supplementary material from "Full allogeneic fusion of embryos in a holothuroid echinoderm" |
title_sort |
supplementary material from "full allogeneic fusion of embryos in a holothuroid echinoderm" |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4100837.v1 https://figshare.com/collections/Supplementary_material_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm_/4100837/1 |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_relation |
https://dx.doi.org/10.1098/rspb.2018.0339 https://dx.doi.org/10.6084/m9.figshare.c.4100837 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4100837.v1 https://doi.org/10.1098/rspb.2018.0339 https://doi.org/10.6084/m9.figshare.c.4100837 |
_version_ |
1766395568271130624 |