Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks ...
Abstract Background Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed mo...
| Main Authors: | , , , , |
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| Format: | Article in Journal/Newspaper |
| Language: | unknown |
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figshare
2018
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| Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.4090880.v1 https://springernature.figshare.com/collections/Cold-pressed_minke_whale_oil_reduces_circulating_LDL_VLDL-cholesterol_lipid_oxidation_and_atherogenesis_in_apolipoprotein_E-deficient_mice_fed_a_Western-type_diet_for_13_weeks/4090880/1 |
| Summary: | Abstract Background Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro. The aim of this study was to investigate whether intake of a high-fat Western-type diet (WD) supplemented with CWO would prevent the development of atherosclerotic lesions in apolipoprotein E-deficient (ApoE−/−) mice. Methods Seventy female ApoE−/− mice were fed a WD containing 1% CWO, CLO or corn oil (CO). Atherosclerotic lesion formation, body and tissue weights, hepatic gene expression together with serum levels of LDL/VLDL-cholesterol, ox-LDL, ... |
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