GC bias lead to increased small amino acids and random coils of proteins in cold-water fishes ...

• Main Authors: Zhang, Dongsheng, Hu, Peng, Liu, Taigang, Wang, Jian, Jiang, Shouwen, Xu, Qianghua, Chen, Liangbiao
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2018
• Subjects: Biophysics; Biochemistry; Physical Sciences not elsewhere classified; Genetics; FOS Biological sciences; Molecular Biology; Physiology; Evolutionary Biology; Environmental Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Ecology; Biological Sciences not elsewhere classified; Marine Biology; Inorganic Chemistry; FOS Chemical sciences; Antarc*; Antarctic; Antarctic Toothfish; atlantic cod; Gadus morhua
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.4088288.v1; https://springernature.figshare.com/collections/GC_bias_lead_to_increased_small_amino_acids_and_random_coils_of_proteins_in_cold-water_fishes/4088288/1

Abstract Background Temperature adaptation of biological molecules is fundamental in evolutionary studies but remains unsolved. Fishes living in cold water are adapted to low temperatures through adaptive modification of their biological molecules, which enables their functioning in extreme cold. To study nucleotide and amino acid preference in cold-water fishes, we investigated the substitution asymmetry of codons and amino acids in protein-coding DNA sequences between cold-water fishes and tropical fishes., The former includes two Antarctic fishes, Dissostichus mawsoni (Antarctic toothfish), Gymnodraco acuticeps (Antarctic dragonfish), and two temperate fishes, Gadus morhua (Atlantic cod) and Gasterosteus aculeatus (stickleback), and the latter includes three tropical fishes, including Danio rerio (zebrafish), Oreochromis niloticus (Nile tilapia) and Xiphophorus maculatus (Platyfish). Results Cold-water fishes showed preference for Guanines and cytosines (GCs) in both synonymous and nonsynonymous codon ...