Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV)
Abstract Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for...
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ftdatacite:10.6084/m9.figshare.c.4030897 2023-05-15T15:29:58+02:00 Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) NiccolĂł Vendramin Alencar, Anna Iburg, Tine Dahle, Maria ĂYstein Wessel Olsen, Anne Rimstad, Espen Olesen, Niels 2018 https://dx.doi.org/10.6084/m9.figshare.c.4030897 https://figshare.com/collections/Piscine_orthoreovirus_infection_in_Atlantic_salmon_Salmo_salar_protects_against_subsequent_challenge_with_infectious_hematopoietic_necrosis_virus_IHNV_/4030897 unknown Figshare https://dx.doi.org/10.1186/s13567-018-0524-z CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases 60506 Virology Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.4030897 https://doi.org/10.1186/s13567-018-0524-z 2021-11-05T12:55:41Z Abstract Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. Article in Journal/Newspaper Atlantic salmon Salmo salar DataCite Metadata Store (German National Library of Science and Technology) Pacific |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases 60506 Virology |
spellingShingle |
Medicine 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases 60506 Virology NiccolĂł Vendramin Alencar, Anna Iburg, Tine Dahle, Maria ĂYstein Wessel Olsen, Anne Rimstad, Espen Olesen, Niels Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
topic_facet |
Medicine 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Science Policy 111714 Mental Health FOS Health sciences 110309 Infectious Diseases 60506 Virology |
description |
Abstract Infectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. |
format |
Article in Journal/Newspaper |
author |
NiccolĂł Vendramin Alencar, Anna Iburg, Tine Dahle, Maria ĂYstein Wessel Olsen, Anne Rimstad, Espen Olesen, Niels |
author_facet |
NiccolĂł Vendramin Alencar, Anna Iburg, Tine Dahle, Maria ĂYstein Wessel Olsen, Anne Rimstad, Espen Olesen, Niels |
author_sort |
NiccolĂł Vendramin |
title |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_short |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_fullStr |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full_unstemmed |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_sort |
piscine orthoreovirus infection in atlantic salmon (salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (ihnv) |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4030897 https://figshare.com/collections/Piscine_orthoreovirus_infection_in_Atlantic_salmon_Salmo_salar_protects_against_subsequent_challenge_with_infectious_hematopoietic_necrosis_virus_IHNV_/4030897 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
https://dx.doi.org/10.1186/s13567-018-0524-z |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4030897 https://doi.org/10.1186/s13567-018-0524-z |
_version_ |
1766360414834130944 |