Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile
Abstract Background Trypanosoma cruzi is the agent of Chagas disease, a major public health problem in Latin America. Many wild and domestic animals are naturally infected with T. cruzi; rodents are one of the groups which have been consistently detected infected in different countries. The aim of t...
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ftdatacite:10.6084/m9.figshare.c.4029751 2023-05-15T18:05:25+02:00 Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile Yefi-Quinteros, Esteban MartĂN, Catalina MuĂąoz-San Bacigalupo, Antonella Correa, Juana Cattan, Pedro 2018 https://dx.doi.org/10.6084/m9.figshare.c.4029751 https://figshare.com/collections/Trypanosoma_cruzi_load_in_synanthropic_rodents_from_rural_areas_in_Chile/4029751 unknown Figshare https://dx.doi.org/10.1186/s13071-018-2771-2 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY 29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Ecology Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.4029751 https://doi.org/10.1186/s13071-018-2771-2 2021-11-05T12:55:41Z Abstract Background Trypanosoma cruzi is the agent of Chagas disease, a major public health problem in Latin America. Many wild and domestic animals are naturally infected with T. cruzi; rodents are one of the groups which have been consistently detected infected in different countries. The aim of this work was to characterize blood T. cruzi load in naturally infected rodents from a Chagas disease endemic region in Chile. Methods Baited traps were set in domestic and peridomestic areas of rural dwellings. The rodents were anesthetized and blood sampled; DNA was extracted and the parasite load was quantified by T. cruzi satellite DNA real-time PCR assays. Results Seventy-one rodents of four species, Rattus rattus, Mus musculus, Phyllotis darwini and Octodon degus, were captured; R. rattus was the most abundant species. Fifty-nine samples (83.1%) were T. cruzi-positive and the median value of the parasite load was 2.99 parasite equivalents (par-eq)/ml. The comparison of frequency of infection or parasite load by species showed no differences. However, one R. rattus presented very elevated parasitemia (1644 par-eq/ml). Conclusions The overall levels of parasitemia were similar to those found in humans in Chile. The high infection levels in exotic and endemic rodents very near to rural settlements increases their relevance as T. cruzi hosts. Article in Journal/Newspaper Rattus rattus DataCite Metadata Store (German National Library of Science and Technology) |
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29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Ecology |
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29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Ecology Yefi-Quinteros, Esteban MartĂN, Catalina MuĂąoz-San Bacigalupo, Antonella Correa, Juana Cattan, Pedro Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
topic_facet |
29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Ecology |
description |
Abstract Background Trypanosoma cruzi is the agent of Chagas disease, a major public health problem in Latin America. Many wild and domestic animals are naturally infected with T. cruzi; rodents are one of the groups which have been consistently detected infected in different countries. The aim of this work was to characterize blood T. cruzi load in naturally infected rodents from a Chagas disease endemic region in Chile. Methods Baited traps were set in domestic and peridomestic areas of rural dwellings. The rodents were anesthetized and blood sampled; DNA was extracted and the parasite load was quantified by T. cruzi satellite DNA real-time PCR assays. Results Seventy-one rodents of four species, Rattus rattus, Mus musculus, Phyllotis darwini and Octodon degus, were captured; R. rattus was the most abundant species. Fifty-nine samples (83.1%) were T. cruzi-positive and the median value of the parasite load was 2.99 parasite equivalents (par-eq)/ml. The comparison of frequency of infection or parasite load by species showed no differences. However, one R. rattus presented very elevated parasitemia (1644 par-eq/ml). Conclusions The overall levels of parasitemia were similar to those found in humans in Chile. The high infection levels in exotic and endemic rodents very near to rural settlements increases their relevance as T. cruzi hosts. |
format |
Article in Journal/Newspaper |
author |
Yefi-Quinteros, Esteban MartĂN, Catalina MuĂąoz-San Bacigalupo, Antonella Correa, Juana Cattan, Pedro |
author_facet |
Yefi-Quinteros, Esteban MartĂN, Catalina MuĂąoz-San Bacigalupo, Antonella Correa, Juana Cattan, Pedro |
author_sort |
Yefi-Quinteros, Esteban |
title |
Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
title_short |
Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
title_full |
Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
title_fullStr |
Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
title_full_unstemmed |
Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile |
title_sort |
trypanosoma cruzi load in synanthropic rodents from rural areas in chile |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4029751 https://figshare.com/collections/Trypanosoma_cruzi_load_in_synanthropic_rodents_from_rural_areas_in_Chile/4029751 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
https://dx.doi.org/10.1186/s13071-018-2771-2 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4029751 https://doi.org/10.1186/s13071-018-2771-2 |
_version_ |
1766176891391180800 |