Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar)
Abstract Background The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing co...
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ftdatacite:10.6084/m9.figshare.c.3970593.v1 2023-05-15T15:30:01+02:00 Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) Nylund, Are Hansen, Haakon Brevik, Øyvind Hustoft, Håvard Markussen, Turhan Plarre, Heidrun Karlsbakk, Egil 2018 https://dx.doi.org/10.6084/m9.figshare.c.3970593.v1 https://figshare.com/collections/Infection_dynamics_and_tissue_tropism_of_Parvicapsula_pseudobranchicola_Myxozoa_Myxosporea_in_farmed_Atlantic_salmon_Salmo_salar_/3970593/1 unknown Figshare https://dx.doi.org/10.1186/s13071-017-2583-9 https://dx.doi.org/10.6084/m9.figshare.c.3970593 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY 29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Cell Biology Ecology 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences 110309 Infectious Diseases FOS Health sciences Computational Biology Collection article 2018 ftdatacite https://doi.org/10.6084/m9.figshare.c.3970593.v1 https://doi.org/10.1186/s13071-017-2583-9 https://doi.org/10.6084/m9.figshare.c.3970593 2021-11-05T12:55:41Z Abstract Background The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiments. The infection dynamics, duration of sporogony, tissue tropism and ability to develop immunity to the parasite in farmed Atlantic salmon is poorly known. We conducted a field experiment, aiming at examining these aspects. Methods Infections in a group of Atlantic salmon were followed from before sea-transfer to the end of the production (604 days). Samples from a range of tissues/sites were analysed using real-time RT-PCR and histology, including in situ hybridization. Results All salmon in the studied population rapidly became infected with P. pseudobranchicola after sea-transfer medio August. Parasite densities in the pseudobranchs peaked in winter (November-January), and decreased markedly to March. Densities thereafter decreased further. Parasite densities in other tissues were low. Parasite stages were initially found to be intravascular in the pseudobranch, but occurred extravascular in the pseudobranch tissue at 3 months post-sea-transfer. Mature spores appeared in the pseudobranchs in the period with high parasite densities in the winter (late November-January), and were released (i.e. disappeared from the fish) in the period January-March. Clinical signs of parvicapsulosis (December-early February) were associated with high parasite densities and inflammation in the pseudobranchs. No evidence for reinfection was seen the second autumn in sea. Conclusions The main site of the parasite in Atlantic salmon is the pseudobranchs. Blood stages occur, but parasite proliferation is primarily associated with extravascular stages in the pseudobranchs. Disease and mortality (parvicapsulosis) coincide with the completion of sporogony. Atlantic salmon appears to develop immunity to P. pseudobranchicola. Further studies should focus on the unknown life-cycle of the parasite, and the pathophysiological effects of the pseudobranch infection that also could affect the eyes and vision. Article in Journal/Newspaper Atlantic salmon Northern Norway Salmo salar DataCite Metadata Store (German National Library of Science and Technology) Norway |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Cell Biology Ecology 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences 110309 Infectious Diseases FOS Health sciences Computational Biology |
spellingShingle |
29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Cell Biology Ecology 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences 110309 Infectious Diseases FOS Health sciences Computational Biology Nylund, Are Hansen, Haakon Brevik, Øyvind Hustoft, Håvard Markussen, Turhan Plarre, Heidrun Karlsbakk, Egil Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
topic_facet |
29999 Physical Sciences not elsewhere classified FOS Physical sciences Medicine Microbiology FOS Biological sciences Cell Biology Ecology 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences 110309 Infectious Diseases FOS Health sciences Computational Biology |
description |
Abstract Background The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiments. The infection dynamics, duration of sporogony, tissue tropism and ability to develop immunity to the parasite in farmed Atlantic salmon is poorly known. We conducted a field experiment, aiming at examining these aspects. Methods Infections in a group of Atlantic salmon were followed from before sea-transfer to the end of the production (604 days). Samples from a range of tissues/sites were analysed using real-time RT-PCR and histology, including in situ hybridization. Results All salmon in the studied population rapidly became infected with P. pseudobranchicola after sea-transfer medio August. Parasite densities in the pseudobranchs peaked in winter (November-January), and decreased markedly to March. Densities thereafter decreased further. Parasite densities in other tissues were low. Parasite stages were initially found to be intravascular in the pseudobranch, but occurred extravascular in the pseudobranch tissue at 3 months post-sea-transfer. Mature spores appeared in the pseudobranchs in the period with high parasite densities in the winter (late November-January), and were released (i.e. disappeared from the fish) in the period January-March. Clinical signs of parvicapsulosis (December-early February) were associated with high parasite densities and inflammation in the pseudobranchs. No evidence for reinfection was seen the second autumn in sea. Conclusions The main site of the parasite in Atlantic salmon is the pseudobranchs. Blood stages occur, but parasite proliferation is primarily associated with extravascular stages in the pseudobranchs. Disease and mortality (parvicapsulosis) coincide with the completion of sporogony. Atlantic salmon appears to develop immunity to P. pseudobranchicola. Further studies should focus on the unknown life-cycle of the parasite, and the pathophysiological effects of the pseudobranch infection that also could affect the eyes and vision. |
format |
Article in Journal/Newspaper |
author |
Nylund, Are Hansen, Haakon Brevik, Øyvind Hustoft, Håvard Markussen, Turhan Plarre, Heidrun Karlsbakk, Egil |
author_facet |
Nylund, Are Hansen, Haakon Brevik, Øyvind Hustoft, Håvard Markussen, Turhan Plarre, Heidrun Karlsbakk, Egil |
author_sort |
Nylund, Are |
title |
Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
title_short |
Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
title_full |
Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
title_fullStr |
Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
title_full_unstemmed |
Infection dynamics and tissue tropism of Parvicapsula pseudobranchicola (Myxozoa: Myxosporea) in farmed Atlantic salmon (Salmo salar) |
title_sort |
infection dynamics and tissue tropism of parvicapsula pseudobranchicola (myxozoa: myxosporea) in farmed atlantic salmon (salmo salar) |
publisher |
Figshare |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3970593.v1 https://figshare.com/collections/Infection_dynamics_and_tissue_tropism_of_Parvicapsula_pseudobranchicola_Myxozoa_Myxosporea_in_farmed_Atlantic_salmon_Salmo_salar_/3970593/1 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Northern Norway Salmo salar |
genre_facet |
Atlantic salmon Northern Norway Salmo salar |
op_relation |
https://dx.doi.org/10.1186/s13071-017-2583-9 https://dx.doi.org/10.6084/m9.figshare.c.3970593 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3970593.v1 https://doi.org/10.1186/s13071-017-2583-9 https://doi.org/10.6084/m9.figshare.c.3970593 |
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