Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis"
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association...
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ftdatacite:10.6084/m9.figshare.c.3942523.v2 2023-05-15T15:34:41+02:00 Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. 2017 https://dx.doi.org/10.6084/m9.figshare.c.3942523.v2 https://figshare.com/collections/Supplementary_material_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis_/3942523/2 unknown Figshare https://dx.doi.org/10.1098/rstb.2016.0447 https://dx.doi.org/10.6084/m9.figshare.c.3942523 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Evolutionary Biology FOS Biological sciences Ecology Collection article 2017 ftdatacite https://doi.org/10.6084/m9.figshare.c.3942523.v2 https://doi.org/10.1098/rstb.2016.0447 https://doi.org/10.6084/m9.figshare.c.3942523 2021-11-05T12:55:41Z Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. Article in Journal/Newspaper Avian Studies DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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topic |
Evolutionary Biology FOS Biological sciences Ecology |
spellingShingle |
Evolutionary Biology FOS Biological sciences Ecology Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
topic_facet |
Evolutionary Biology FOS Biological sciences Ecology |
description |
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. |
format |
Article in Journal/Newspaper |
author |
Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. |
author_facet |
Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. |
author_sort |
Wilbourn, Rachael V. |
title |
Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
title_short |
Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
title_full |
Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
title_fullStr |
Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
title_full_unstemmed |
Supplementary material from "The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
title_sort |
supplementary material from "the relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis" |
publisher |
Figshare |
publishDate |
2017 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3942523.v2 https://figshare.com/collections/Supplementary_material_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis_/3942523/2 |
genre |
Avian Studies |
genre_facet |
Avian Studies |
op_relation |
https://dx.doi.org/10.1098/rstb.2016.0447 https://dx.doi.org/10.6084/m9.figshare.c.3942523 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3942523.v2 https://doi.org/10.1098/rstb.2016.0447 https://doi.org/10.6084/m9.figshare.c.3942523 |
_version_ |
1766364989923262464 |