Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study
Abstract Background Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammat...
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ftdatacite:10.6084/m9.figshare.c.3734218 2023-05-15T17:45:13+02:00 Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study Bodén, Stina Wennberg, Maria Guelpen, Bethany Van Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Nitin Shivappa Hebert, James Nilsson, Lena 2017 https://dx.doi.org/10.6084/m9.figshare.c.3734218 https://figshare.com/collections/Dietary_inflammatory_index_and_risk_of_first_myocardial_infarction_a_prospective_population-based_study/3734218 unknown Figshare https://dx.doi.org/10.1186/s12937-017-0243-8 CC BY https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine Science Policy Collection article 2017 ftdatacite https://doi.org/10.6084/m9.figshare.c.3734218 https://doi.org/10.1186/s12937-017-0243-8 2021-11-05T12:55:41Z Abstract Background Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DIITM), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up. Method We conducted a prospective case–control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986–2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n = 605) of the study population. Results Male participants with the most pro-inflammatory DII scores had an increased risk of MI [ORQ4vsQ1 = 1.57 (95% CI 1.21–2.02) P trend = 0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [ORQ4vsQ1 = 1.50 (95% CI 1.14–1.99), P trend = 0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03–0.14) and 6% higher IL-6 (95% CI 0.02–0.11) in 605 controls with biomarker data available. Conclusion A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease. Article in Journal/Newspaper Northern Sweden DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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unknown |
topic |
Medicine Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine Science Policy |
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Medicine Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine Science Policy Bodén, Stina Wennberg, Maria Guelpen, Bethany Van Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Nitin Shivappa Hebert, James Nilsson, Lena Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
topic_facet |
Medicine Biotechnology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine Science Policy |
description |
Abstract Background Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DIITM), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up. Method We conducted a prospective case–control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986–2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n = 605) of the study population. Results Male participants with the most pro-inflammatory DII scores had an increased risk of MI [ORQ4vsQ1 = 1.57 (95% CI 1.21–2.02) P trend = 0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [ORQ4vsQ1 = 1.50 (95% CI 1.14–1.99), P trend = 0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03–0.14) and 6% higher IL-6 (95% CI 0.02–0.11) in 605 controls with biomarker data available. Conclusion A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease. |
format |
Article in Journal/Newspaper |
author |
Bodén, Stina Wennberg, Maria Guelpen, Bethany Van Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Nitin Shivappa Hebert, James Nilsson, Lena |
author_facet |
Bodén, Stina Wennberg, Maria Guelpen, Bethany Van Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Nitin Shivappa Hebert, James Nilsson, Lena |
author_sort |
Bodén, Stina |
title |
Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_short |
Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_full |
Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_fullStr |
Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_full_unstemmed |
Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_sort |
dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
publisher |
Figshare |
publishDate |
2017 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3734218 https://figshare.com/collections/Dietary_inflammatory_index_and_risk_of_first_myocardial_infarction_a_prospective_population-based_study/3734218 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://dx.doi.org/10.1186/s12937-017-0243-8 |
op_rights |
CC BY https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3734218 https://doi.org/10.1186/s12937-017-0243-8 |
_version_ |
1766148064530137088 |