Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes"
Endothermy is an evolutionary innovation in Eutherian mammals and birds. In Eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including bir...
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ftdatacite:10.6084/m9.figshare.c.3649910 2023-05-15T17:53:50+02:00 Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" McGaugh, Suzanne Schwartz, Tonia S. 2016 https://dx.doi.org/10.6084/m9.figshare.c.3649910 https://figshare.com/collections/Supplementary_material_from_Here_and_there_but_not_everywhere_repeated_loss_of_i_uncoupling_protein_1_i_in_amniotes_/3649910 unknown Figshare https://dx.doi.org/10.1098/rsbl.2016.0749 CC BY https://creativecommons.org/licenses/by/4.0 CC-BY Evolutionary Biology FOS Biological sciences Bioinformatics FOS Computer and information sciences Collection article 2016 ftdatacite https://doi.org/10.6084/m9.figshare.c.3649910 https://doi.org/10.1098/rsbl.2016.0749 2021-11-05T12:55:41Z Endothermy is an evolutionary innovation in Eutherian mammals and birds. In Eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was likely lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only Eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. Article in Journal/Newspaper Orca DataCite Metadata Store (German National Library of Science and Technology) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
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language |
unknown |
topic |
Evolutionary Biology FOS Biological sciences Bioinformatics FOS Computer and information sciences |
spellingShingle |
Evolutionary Biology FOS Biological sciences Bioinformatics FOS Computer and information sciences McGaugh, Suzanne Schwartz, Tonia S. Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
topic_facet |
Evolutionary Biology FOS Biological sciences Bioinformatics FOS Computer and information sciences |
description |
Endothermy is an evolutionary innovation in Eutherian mammals and birds. In Eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was likely lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only Eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. |
format |
Article in Journal/Newspaper |
author |
McGaugh, Suzanne Schwartz, Tonia S. |
author_facet |
McGaugh, Suzanne Schwartz, Tonia S. |
author_sort |
McGaugh, Suzanne |
title |
Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
title_short |
Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
title_full |
Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
title_fullStr |
Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
title_full_unstemmed |
Supplementary material from "Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
title_sort |
supplementary material from "here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes" |
publisher |
Figshare |
publishDate |
2016 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3649910 https://figshare.com/collections/Supplementary_material_from_Here_and_there_but_not_everywhere_repeated_loss_of_i_uncoupling_protein_1_i_in_amniotes_/3649910 |
genre |
Orca |
genre_facet |
Orca |
op_relation |
https://dx.doi.org/10.1098/rsbl.2016.0749 |
op_rights |
CC BY https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3649910 https://doi.org/10.1098/rsbl.2016.0749 |
_version_ |
1766161534035165184 |