Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon
Abstract All viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown to use the gills as it...
Main Authors: | , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
Figshare
2015
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.3644606 https://figshare.com/collections/Infectious_salmon_anaemia_virus_ISAV_mucosal_infection_in_Atlantic_salmon/3644606 |
id |
ftdatacite:10.6084/m9.figshare.c.3644606 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.c.3644606 2023-05-15T15:30:47+02:00 Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon Aamelfot, Maria McBeath, Alastair Debes Christiansen Matejusova, Iveta Falk, Knut 2015 https://dx.doi.org/10.6084/m9.figshare.c.3644606 https://figshare.com/collections/Infectious_salmon_anaemia_virus_ISAV_mucosal_infection_in_Atlantic_salmon/3644606 unknown Figshare https://dx.doi.org/10.1186/s13567-015-0265-1 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Microbiology FOS Biological sciences Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Computational Biology Collection article 2015 ftdatacite https://doi.org/10.6084/m9.figshare.c.3644606 https://doi.org/10.1186/s13567-015-0265-1 2021-11-05T12:55:41Z Abstract All viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown to use the gills as its entry point. However, other entry ports have not been investigated despite the expression of virus receptors on the surface of epithelial cells in the skin, the gastrointestinal (GI) tract and the conjunctiva. Here we investigate the ISAV mucosal infection in Atlantic salmon after experimental immersion (bath) challenge and in farmed fish collected from a confirmed outbreak of ISA in Norway. We show for the first time evidence of early replication in several mucosal surfaces in addition to the gills, including the pectoral fin, skin and GI tract suggesting several potential entry points for the virus. Initially, the infection is localized and primarily infecting epithelial cells, however at later stages it becomes systemic, infecting the endothelial cells lining the circulatory system. Viruses of low and high virulence used in the challenge revealed possible variation in virus progression during infection at the mucosal surfaces. Article in Journal/Newspaper Atlantic salmon Salmo salar DataCite Metadata Store (German National Library of Science and Technology) Norway |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine Microbiology FOS Biological sciences Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Computational Biology |
spellingShingle |
Medicine Microbiology FOS Biological sciences Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Computational Biology Aamelfot, Maria McBeath, Alastair Debes Christiansen Matejusova, Iveta Falk, Knut Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
topic_facet |
Medicine Microbiology FOS Biological sciences Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Computational Biology |
description |
Abstract All viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown to use the gills as its entry point. However, other entry ports have not been investigated despite the expression of virus receptors on the surface of epithelial cells in the skin, the gastrointestinal (GI) tract and the conjunctiva. Here we investigate the ISAV mucosal infection in Atlantic salmon after experimental immersion (bath) challenge and in farmed fish collected from a confirmed outbreak of ISA in Norway. We show for the first time evidence of early replication in several mucosal surfaces in addition to the gills, including the pectoral fin, skin and GI tract suggesting several potential entry points for the virus. Initially, the infection is localized and primarily infecting epithelial cells, however at later stages it becomes systemic, infecting the endothelial cells lining the circulatory system. Viruses of low and high virulence used in the challenge revealed possible variation in virus progression during infection at the mucosal surfaces. |
format |
Article in Journal/Newspaper |
author |
Aamelfot, Maria McBeath, Alastair Debes Christiansen Matejusova, Iveta Falk, Knut |
author_facet |
Aamelfot, Maria McBeath, Alastair Debes Christiansen Matejusova, Iveta Falk, Knut |
author_sort |
Aamelfot, Maria |
title |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_short |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_full |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_fullStr |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_full_unstemmed |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_sort |
infectious salmon anaemia virus (isav) mucosal infection in atlantic salmon |
publisher |
Figshare |
publishDate |
2015 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3644606 https://figshare.com/collections/Infectious_salmon_anaemia_virus_ISAV_mucosal_infection_in_Atlantic_salmon/3644606 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
https://dx.doi.org/10.1186/s13567-015-0265-1 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3644606 https://doi.org/10.1186/s13567-015-0265-1 |
_version_ |
1766361228296323072 |