Dietary phytochemicals modulate skin gene expression profiles and result in reduced lice counts after experimental infection in Atlantic salmon

• Main Authors: Holm, Helle Jodaa, Wadsworth, Simon, Anne-Kari Bjelland, Krasnov, Aleksei, Evensen, Øystein, Skugor, Stanko
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Figshare 2016
• Subjects: Medicine; Genetics; FOS Biological sciences; Physiology; Ecology; Immunology; FOS Clinical medicine; 69999 Biological Sciences not elsewhere classified; 110309 Infectious Diseases; FOS Health sciences; 60506 Virology; Computational Biology; Atlantic salmon
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.3628829; https://figshare.com/collections/Dietary_phytochemicals_modulate_skin_gene_expression_profiles_and_result_in_reduced_lice_counts_after_experimental_infection_in_Atlantic_salmon/3628829

Abstract Background The use of phytochemicals is a promising solution in biological control against salmon louse (Lepeophtheirus salmonis). Glucosinolates belong to a diverse group of compounds used as protection against herbivores by plants in the family Brassicaceae, while in vertebrates, ingested glucosinolates exert health-promoting effects due to their antioxidant and detoxifying properties as well as effects on cell proliferation and growth. The aim of this study was to investigate if Atlantic salmon fed two different doses of glucosinolate-enriched feeds would be protected against lice infection. The effects of feeding high dose of glucosinolates before the infection, and of high and low doses five weeks into the infection were studied. Methods Skin was screened by 15 k oligonucleotide microarray and qPCR. Results A 25 % reduction (P