Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-di...
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ftdatacite:10.6084/m9.figshare.c.3627929 2023-05-15T18:34:47+02:00 Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn 2016 https://dx.doi.org/10.6084/m9.figshare.c.3627929 https://figshare.com/collections/Central_obesity_associates_with_renal_hyperfiltration_in_the_non-diabetic_general_population_a_cross-sectional_study/3627929 unknown Figshare https://dx.doi.org/10.1186/s12882-016-0386-4 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Marine Biology Collection article 2016 ftdatacite https://doi.org/10.6084/m9.figshare.c.3627929 https://doi.org/10.1186/s12882-016-0386-4 2021-11-05T12:55:41Z Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. Article in Journal/Newspaper Tromsø DataCite Metadata Store (German National Library of Science and Technology) Tromsø The Waist ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
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ftdatacite |
language |
unknown |
topic |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Marine Biology |
spellingShingle |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Marine Biology Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
topic_facet |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Marine Biology |
description |
Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. |
format |
Article in Journal/Newspaper |
author |
Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn |
author_facet |
Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn |
author_sort |
Stefansson, Vidar |
title |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_short |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_fullStr |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full_unstemmed |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_sort |
central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
publisher |
Figshare |
publishDate |
2016 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3627929 https://figshare.com/collections/Central_obesity_associates_with_renal_hyperfiltration_in_the_non-diabetic_general_population_a_cross-sectional_study/3627929 |
long_lat |
ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
geographic |
Tromsø The Waist |
geographic_facet |
Tromsø The Waist |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://dx.doi.org/10.1186/s12882-016-0386-4 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3627929 https://doi.org/10.1186/s12882-016-0386-4 |
_version_ |
1766219696414130176 |