Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe
Abstract Background The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs225...
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ftdatacite:10.6084/m9.figshare.c.3620741.v1 2023-05-15T17:02:55+02:00 Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe Butovskaya, Polina Lazebny, Oleg Sukhodolskaya, Evgeniya Vasiliev, Vasily Dronova, Daria Fedenok, Juliya Aracelli Rosa Peletskaya, Elena Ryskov, Alexey Butovskaya, Marina 2016 https://dx.doi.org/10.6084/m9.figshare.c.3620741.v1 https://figshare.com/collections/Polymorphisms_of_two_loci_at_the_oxytocin_receptor_gene_in_populations_of_Africa_Asia_and_South_Europe/3620741/1 unknown Figshare https://dx.doi.org/10.1186/s12863-015-0323-8 https://dx.doi.org/10.6084/m9.figshare.c.3620741 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Genetics FOS Biological sciences Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology 69999 Biological Sciences not elsewhere classified Collection article 2016 ftdatacite https://doi.org/10.6084/m9.figshare.c.3620741.v1 https://doi.org/10.1186/s12863-015-0323-8 https://doi.org/10.6084/m9.figshare.c.3620741 2021-11-05T12:55:41Z Abstract Background The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. Results These data were compared with each other and with 14 samples from the corresponding regions retrieved from the 1000 Genomes database. Low level of heterozygosity was observed for both SNPs in all populations in this study (rs53576: Catalonian, Hobs = 0.413; Hadza, Hobs = 0.556; sr2254698: Khanty-Mansi, Hobs = 0.250; Datoga, Hobs = 0.550). The amount of variance due to regional variability was almost equal for both SNPs (rs53576: FRT = 0.086, rs2554298: FRT = 0.072), whereas variance for the population level of variability was twice bigger for rs2554298 (rs53576: FST = 0.127, rs2554298: FST = 0.162). Pairwise coefficients of fixation demonstrate that the Hadza were well differentiated from other African populations except of Datoga, the Datoga were weakly differentiated from other African origin populations, the Ob Ugric people were extremely differentiated from all other populations. Catalans were extremely differentiated of Asian populations. Conclusions It is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans. Article in Journal/Newspaper khanty khanty-mansi Mansi DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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unknown |
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Genetics FOS Biological sciences Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology 69999 Biological Sciences not elsewhere classified |
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Genetics FOS Biological sciences Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology 69999 Biological Sciences not elsewhere classified Butovskaya, Polina Lazebny, Oleg Sukhodolskaya, Evgeniya Vasiliev, Vasily Dronova, Daria Fedenok, Juliya Aracelli Rosa Peletskaya, Elena Ryskov, Alexey Butovskaya, Marina Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
topic_facet |
Genetics FOS Biological sciences Evolutionary Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology 69999 Biological Sciences not elsewhere classified |
description |
Abstract Background The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. Results These data were compared with each other and with 14 samples from the corresponding regions retrieved from the 1000 Genomes database. Low level of heterozygosity was observed for both SNPs in all populations in this study (rs53576: Catalonian, Hobs = 0.413; Hadza, Hobs = 0.556; sr2254698: Khanty-Mansi, Hobs = 0.250; Datoga, Hobs = 0.550). The amount of variance due to regional variability was almost equal for both SNPs (rs53576: FRT = 0.086, rs2554298: FRT = 0.072), whereas variance for the population level of variability was twice bigger for rs2554298 (rs53576: FST = 0.127, rs2554298: FST = 0.162). Pairwise coefficients of fixation demonstrate that the Hadza were well differentiated from other African populations except of Datoga, the Datoga were weakly differentiated from other African origin populations, the Ob Ugric people were extremely differentiated from all other populations. Catalans were extremely differentiated of Asian populations. Conclusions It is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans. |
format |
Article in Journal/Newspaper |
author |
Butovskaya, Polina Lazebny, Oleg Sukhodolskaya, Evgeniya Vasiliev, Vasily Dronova, Daria Fedenok, Juliya Aracelli Rosa Peletskaya, Elena Ryskov, Alexey Butovskaya, Marina |
author_facet |
Butovskaya, Polina Lazebny, Oleg Sukhodolskaya, Evgeniya Vasiliev, Vasily Dronova, Daria Fedenok, Juliya Aracelli Rosa Peletskaya, Elena Ryskov, Alexey Butovskaya, Marina |
author_sort |
Butovskaya, Polina |
title |
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
title_short |
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
title_full |
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
title_fullStr |
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
title_full_unstemmed |
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe |
title_sort |
polymorphisms of two loci at the oxytocin receptor gene in populations of africa, asia and south europe |
publisher |
Figshare |
publishDate |
2016 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3620741.v1 https://figshare.com/collections/Polymorphisms_of_two_loci_at_the_oxytocin_receptor_gene_in_populations_of_Africa_Asia_and_South_Europe/3620741/1 |
genre |
khanty khanty-mansi Mansi |
genre_facet |
khanty khanty-mansi Mansi |
op_relation |
https://dx.doi.org/10.1186/s12863-015-0323-8 https://dx.doi.org/10.6084/m9.figshare.c.3620741 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3620741.v1 https://doi.org/10.1186/s12863-015-0323-8 https://doi.org/10.6084/m9.figshare.c.3620741 |
_version_ |
1766056618808573952 |