A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)
Abstract Background The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen recept...
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ftdatacite:10.6084/m9.figshare.c.3604175 2023-05-15T18:50:21+02:00 A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) Prentice, Melanie Bowman, Jeff Wilson, Paul 2015 https://dx.doi.org/10.6084/m9.figshare.c.3604175 https://figshare.com/collections/A_test_of_somatic_mosaicism_in_the_androgen_receptor_gene_of_Canada_lynx_Lynx_canadensis_/3604175 unknown Figshare https://dx.doi.org/10.1186/s12863-015-0284-y CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Collection article 2015 ftdatacite https://doi.org/10.6084/m9.figshare.c.3604175 https://doi.org/10.1186/s12863-015-0284-y 2021-11-05T12:55:41Z Abstract Background The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. Article in Journal/Newspaper Lynx Lynx lynx lynx DataCite Metadata Store (German National Library of Science and Technology) Canada |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
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language |
unknown |
topic |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology |
spellingShingle |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Prentice, Melanie Bowman, Jeff Wilson, Paul A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
topic_facet |
Medicine Genetics FOS Biological sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology |
description |
Abstract Background The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. |
format |
Article in Journal/Newspaper |
author |
Prentice, Melanie Bowman, Jeff Wilson, Paul |
author_facet |
Prentice, Melanie Bowman, Jeff Wilson, Paul |
author_sort |
Prentice, Melanie |
title |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_short |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_fullStr |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full_unstemmed |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_sort |
test of somatic mosaicism in the androgen receptor gene of canada lynx (lynx canadensis) |
publisher |
Figshare |
publishDate |
2015 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.3604175 https://figshare.com/collections/A_test_of_somatic_mosaicism_in_the_androgen_receptor_gene_of_Canada_lynx_Lynx_canadensis_/3604175 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_relation |
https://dx.doi.org/10.1186/s12863-015-0284-y |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.3604175 https://doi.org/10.1186/s12863-015-0284-y |
_version_ |
1766244070058885120 |