DNA methylation as a mechanism to increase adaptive potential in invertebrates
Funded NSF Proposal Summary: The study of DNA methylation is providing remarkable insight into gene regulation and the complex mechanisms associated with phenotypic variation and adaptation to environmental change. DNA methylation is found from prokaryotes to humans, however there is dramatic divers...
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ftdatacite:10.6084/m9.figshare.97107.v1 2023-05-15T15:58:41+02:00 DNA methylation as a mechanism to increase adaptive potential in invertebrates Roberts, Steven 2012 https://dx.doi.org/10.6084/m9.figshare.97107.v1 https://figshare.com/articles/journal_contribution/DNA_methylation_as_a_mechanism_to_increase_adaptive_potential_in_invertebrates/97107/1 unknown figshare https://dx.doi.org/10.6084/m9.figshare.97107 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Molecular Biology Evolutionary Biology FOS Biological sciences Ecology Text article-journal Journal contribution ScholarlyArticle 2012 ftdatacite https://doi.org/10.6084/m9.figshare.97107.v1 https://doi.org/10.6084/m9.figshare.97107 2021-11-05T12:55:41Z Funded NSF Proposal Summary: The study of DNA methylation is providing remarkable insight into gene regulation and the complex mechanisms associated with phenotypic variation and adaptation to environmental change. DNA methylation is found from prokaryotes to humans, however there is dramatic diversity in characteristics - from species where this phenomenon is absent, to cases where the genome is globally methylated. Although DNA methylation is considered an evolutionarily ancient epigenetic mechanism, the role and evolutionary significance of this process is not fully understood. The overall goal of the research is to use the Pacific oyster, Crassostrea gigas , as a model system to evaluate the potentially transformative theory that the absence of germline methylation in genes involved in adapting to changing conditions has evolved to increase adaptive potential in organisms exposed to heterogeneous environments. The Pacific oyster is an excellent model to use for the proposed project because it is one of only a few invertebrates where DNA methylation has been described, there are considerable genomic resources available, and the Pacific oyster is a key bioindicator species that can provide us with a better understanding of how species respond to fluctuating environmental conditions. Text Crassostrea gigas Pacific oyster DataCite Metadata Store (German National Library of Science and Technology) Pacific |
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Molecular Biology Evolutionary Biology FOS Biological sciences Ecology |
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Molecular Biology Evolutionary Biology FOS Biological sciences Ecology Roberts, Steven DNA methylation as a mechanism to increase adaptive potential in invertebrates |
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Molecular Biology Evolutionary Biology FOS Biological sciences Ecology |
description |
Funded NSF Proposal Summary: The study of DNA methylation is providing remarkable insight into gene regulation and the complex mechanisms associated with phenotypic variation and adaptation to environmental change. DNA methylation is found from prokaryotes to humans, however there is dramatic diversity in characteristics - from species where this phenomenon is absent, to cases where the genome is globally methylated. Although DNA methylation is considered an evolutionarily ancient epigenetic mechanism, the role and evolutionary significance of this process is not fully understood. The overall goal of the research is to use the Pacific oyster, Crassostrea gigas , as a model system to evaluate the potentially transformative theory that the absence of germline methylation in genes involved in adapting to changing conditions has evolved to increase adaptive potential in organisms exposed to heterogeneous environments. The Pacific oyster is an excellent model to use for the proposed project because it is one of only a few invertebrates where DNA methylation has been described, there are considerable genomic resources available, and the Pacific oyster is a key bioindicator species that can provide us with a better understanding of how species respond to fluctuating environmental conditions. |
format |
Text |
author |
Roberts, Steven |
author_facet |
Roberts, Steven |
author_sort |
Roberts, Steven |
title |
DNA methylation as a mechanism to increase adaptive potential in invertebrates |
title_short |
DNA methylation as a mechanism to increase adaptive potential in invertebrates |
title_full |
DNA methylation as a mechanism to increase adaptive potential in invertebrates |
title_fullStr |
DNA methylation as a mechanism to increase adaptive potential in invertebrates |
title_full_unstemmed |
DNA methylation as a mechanism to increase adaptive potential in invertebrates |
title_sort |
dna methylation as a mechanism to increase adaptive potential in invertebrates |
publisher |
figshare |
publishDate |
2012 |
url |
https://dx.doi.org/10.6084/m9.figshare.97107.v1 https://figshare.com/articles/journal_contribution/DNA_methylation_as_a_mechanism_to_increase_adaptive_potential_in_invertebrates/97107/1 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
https://dx.doi.org/10.6084/m9.figshare.97107 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.97107.v1 https://doi.org/10.6084/m9.figshare.97107 |
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1766394456982945792 |