Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.)
Ethoxyquin (EQ) is an antioxidant supplemented to feed ingredients, mainly fish meal, which is currently under re-evaluation for use in the food production chain. EQ is partly metabolized into several metabolites of which the ethoxyquin dimer (EQDM) accumulates most in the farmed fish fillet. In thi...
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2019
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ftdatacite:10.6084/m9.figshare.8089046.v1 2023-05-15T15:30:37+02:00 Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) M.H.G. Berntssen R. Hoogenveen A. Bernhard A.-K. Lundebye R Ørnsrud M.J. Zeilmaker 2019 https://dx.doi.org/10.6084/m9.figshare.8089046.v1 https://tandf.figshare.com/articles/Modelling_of_the_feed-to-fillet_transfer_of_ethoxyquin_and_one_of_its_main_metabolites_ethoxyquin_dimer_to_the_fillet_of_farmed_Atlantic_salmon_i_Salmon_salar_i_L_/8089046/1 unknown Taylor & Francis https://dx.doi.org/10.1080/19440049.2019.1605208 https://dx.doi.org/10.6084/m9.figshare.8089046 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences Science Policy Text article-journal Journal contribution ScholarlyArticle 2019 ftdatacite https://doi.org/10.6084/m9.figshare.8089046.v1 https://doi.org/10.1080/19440049.2019.1605208 https://doi.org/10.6084/m9.figshare.8089046 2021-11-05T12:55:41Z Ethoxyquin (EQ) is an antioxidant supplemented to feed ingredients, mainly fish meal, which is currently under re-evaluation for use in the food production chain. EQ is partly metabolized into several metabolites of which the ethoxyquin dimer (EQDM) accumulates most in the farmed fish fillet. In this study, the feed-to-fillet transfer of dietary EQ and EQDM in Atlantic salmon fillet was investigated, and a physiologically based pharmacokinetic (PBPK-) two-compartmental model was developed, based on experimental determined EQ and EQDM uptake, metabolism, and elimination kinetics. The model was verified with an external data-set and used to simulate the long term (>1.5 years) EQ and EQDM feed-to fillet transfer in Atlantic salmon under realistic farming conditions such as the seasonal fluctuations in feed intake, growth, and fillet fat deposition. The model predictions showed that initial EQDM levels in juvenile fish are the driving factor in final levels found in food-producing animals, while for EQ the levels in feed, and seasonal variations were the driving factor for food EQ levels. Text Atlantic salmon DataCite Metadata Store (German National Library of Science and Technology) |
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59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences Science Policy |
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59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences Science Policy M.H.G. Berntssen R. Hoogenveen A. Bernhard A.-K. Lundebye R Ørnsrud M.J. Zeilmaker Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
topic_facet |
59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Inorganic Chemistry FOS Chemical sciences Science Policy |
description |
Ethoxyquin (EQ) is an antioxidant supplemented to feed ingredients, mainly fish meal, which is currently under re-evaluation for use in the food production chain. EQ is partly metabolized into several metabolites of which the ethoxyquin dimer (EQDM) accumulates most in the farmed fish fillet. In this study, the feed-to-fillet transfer of dietary EQ and EQDM in Atlantic salmon fillet was investigated, and a physiologically based pharmacokinetic (PBPK-) two-compartmental model was developed, based on experimental determined EQ and EQDM uptake, metabolism, and elimination kinetics. The model was verified with an external data-set and used to simulate the long term (>1.5 years) EQ and EQDM feed-to fillet transfer in Atlantic salmon under realistic farming conditions such as the seasonal fluctuations in feed intake, growth, and fillet fat deposition. The model predictions showed that initial EQDM levels in juvenile fish are the driving factor in final levels found in food-producing animals, while for EQ the levels in feed, and seasonal variations were the driving factor for food EQ levels. |
format |
Text |
author |
M.H.G. Berntssen R. Hoogenveen A. Bernhard A.-K. Lundebye R Ørnsrud M.J. Zeilmaker |
author_facet |
M.H.G. Berntssen R. Hoogenveen A. Bernhard A.-K. Lundebye R Ørnsrud M.J. Zeilmaker |
author_sort |
M.H.G. Berntssen |
title |
Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
title_short |
Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
title_full |
Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
title_fullStr |
Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
title_full_unstemmed |
Modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed Atlantic salmon ( Salmon salar L.) |
title_sort |
modelling of the feed-to-fillet transfer of ethoxyquin and one of its main metabolites, ethoxyquin dimer, to the fillet of farmed atlantic salmon ( salmon salar l.) |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
https://dx.doi.org/10.6084/m9.figshare.8089046.v1 https://tandf.figshare.com/articles/Modelling_of_the_feed-to-fillet_transfer_of_ethoxyquin_and_one_of_its_main_metabolites_ethoxyquin_dimer_to_the_fillet_of_farmed_Atlantic_salmon_i_Salmon_salar_i_L_/8089046/1 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
https://dx.doi.org/10.1080/19440049.2019.1605208 https://dx.doi.org/10.6084/m9.figshare.8089046 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.8089046.v1 https://doi.org/10.1080/19440049.2019.1605208 https://doi.org/10.6084/m9.figshare.8089046 |
_version_ |
1766361066108878848 |