Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods ...

• Main Authors: Ding, Jing, Yang, Zhijun, Zhao, Yu, Fang, Weizhen, Lu, Qun
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2019
• Subjects: Biophysics; Biochemistry; Microbiology; FOS Biological sciences; Genetics; Biotechnology; Chemical Sciences not elsewhere classified; Infectious Diseases; FOS Health sciences; Antarc*; Antarctica
• Online Access: https://dx.doi.org/10.6084/m9.figshare.7604639.v1; https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_ethyl_i_R_i_-2-benzyloxy-2-isopropylhydrogenmalonate_a_useful_combination_of_chemical_synthesis_with_enzymatic_methods/7604639/1

Ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. Novozyme 435 catalyzed hydrolysis reaction to prepare the key intermediate for the synthesis of peptide side chain of ergopeptides. ...