Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods ...
Ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corr...
Main Authors: | , , , , |
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Format: | Text |
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Taylor & Francis
2019
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.7604639 https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_ethyl_i_R_i_-2-benzyloxy-2-isopropylhydrogenmalonate_a_useful_combination_of_chemical_synthesis_with_enzymatic_methods/7604639 |
Summary: | Ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. Novozyme 435 catalyzed hydrolysis reaction to prepare the key intermediate for the synthesis of peptide side chain of ergopeptides. ... |
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