Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study
Objective : To assess the strength of the effect of cardiovascular risk factors on the incidence of giant cell arteritis (GCA) in a general population context. Method : Data from the Reykjavik Study (RS), a population-based cohort study focusing on cardiovascular disease, were used. Everyone born in...
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ftdatacite:10.6084/m9.figshare.7370222 2023-05-15T16:48:49+02:00 Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study G Tomasson J Bjornsson Y Zhang V Gudnason PA Merkel 2018 https://dx.doi.org/10.6084/m9.figshare.7370222 https://tandf.figshare.com/articles/Cardiovascular_risk_factors_and_incident_giant_cell_arteritis_a_population-based_cohort_study/7370222 unknown Taylor & Francis https://dx.doi.org/10.1080/03009742.2018.1506821 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Hematology Text article-journal Journal contribution ScholarlyArticle 2018 ftdatacite https://doi.org/10.6084/m9.figshare.7370222 https://doi.org/10.1080/03009742.2018.1506821 2021-11-05T12:55:41Z Objective : To assess the strength of the effect of cardiovascular risk factors on the incidence of giant cell arteritis (GCA) in a general population context. Method : Data from the Reykjavik Study (RS), a population-based cohort study focusing on cardiovascular disease, were used. Everyone born in 1907–1935 living in Reykjavik, Iceland, or adjacent communities on 1 December 1967 were invited to participate. Subjects attended a study visit in 1967–1996 and information on cardiovascular risk factors [smoking habits, blood pressure, diabetes, body mass index (BMI), and serum cholesterol] was obtained. All temporal artery biopsies obtained from members of the RS cohort were re-examined by a single pathologist with expertise in vascular pathology. Effects of risk factors on GCA occurrence are expressed as incidence rate ratios (IRRs) with 95% confidence intervals (CIs). Results : Altogether, 19 241 subjects contributed a median of 23.1 (interquartile range 17.6–29.4) years after the age of 50 to this analysis. During 444 126 person-years of follow-up, 194 subjects developed GCA, corresponding to an incidence rate of 43.6 (95% CI 37.8–50.2) per 100 000 person-years. Being overweight or obese were inversely associated with GCA, especially in women [IRRs 0.70 (0.48–1.02) and 0.31 (0.14–0.71), respectively]. There was a weaker association between BMI and incident GCA in men. Smoking was inversely associated with GCA in men [IRR 0.47 (0.27–0.81)], but not in women. Conclusions : The incidence of GCA in Iceland is very high. High BMI protects against the occurrence of GCA, and smoking may protect against GCA in men. Text Iceland DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Hematology |
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Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Hematology G Tomasson J Bjornsson Y Zhang V Gudnason PA Merkel Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
topic_facet |
Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Hematology |
description |
Objective : To assess the strength of the effect of cardiovascular risk factors on the incidence of giant cell arteritis (GCA) in a general population context. Method : Data from the Reykjavik Study (RS), a population-based cohort study focusing on cardiovascular disease, were used. Everyone born in 1907–1935 living in Reykjavik, Iceland, or adjacent communities on 1 December 1967 were invited to participate. Subjects attended a study visit in 1967–1996 and information on cardiovascular risk factors [smoking habits, blood pressure, diabetes, body mass index (BMI), and serum cholesterol] was obtained. All temporal artery biopsies obtained from members of the RS cohort were re-examined by a single pathologist with expertise in vascular pathology. Effects of risk factors on GCA occurrence are expressed as incidence rate ratios (IRRs) with 95% confidence intervals (CIs). Results : Altogether, 19 241 subjects contributed a median of 23.1 (interquartile range 17.6–29.4) years after the age of 50 to this analysis. During 444 126 person-years of follow-up, 194 subjects developed GCA, corresponding to an incidence rate of 43.6 (95% CI 37.8–50.2) per 100 000 person-years. Being overweight or obese were inversely associated with GCA, especially in women [IRRs 0.70 (0.48–1.02) and 0.31 (0.14–0.71), respectively]. There was a weaker association between BMI and incident GCA in men. Smoking was inversely associated with GCA in men [IRR 0.47 (0.27–0.81)], but not in women. Conclusions : The incidence of GCA in Iceland is very high. High BMI protects against the occurrence of GCA, and smoking may protect against GCA in men. |
format |
Text |
author |
G Tomasson J Bjornsson Y Zhang V Gudnason PA Merkel |
author_facet |
G Tomasson J Bjornsson Y Zhang V Gudnason PA Merkel |
author_sort |
G Tomasson |
title |
Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
title_short |
Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
title_full |
Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
title_fullStr |
Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
title_full_unstemmed |
Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
title_sort |
cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study |
publisher |
Taylor & Francis |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.7370222 https://tandf.figshare.com/articles/Cardiovascular_risk_factors_and_incident_giant_cell_arteritis_a_population-based_cohort_study/7370222 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://dx.doi.org/10.1080/03009742.2018.1506821 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.7370222 https://doi.org/10.1080/03009742.2018.1506821 |
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1766038909618225152 |