Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor
Alzheimer´s disease (AD) is the most common form of dementia involving Aβ and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders na...
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ftdatacite:10.6084/m9.figshare.7294418.v1 2023-05-15T13:59:29+02:00 Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos 2018 https://dx.doi.org/10.6084/m9.figshare.7294418.v1 https://tandf.figshare.com/articles/Continental_and_Antarctic_Lichens_isolation_identification_and_molecular_modeling_of_the_depside_tenuiorin_from_the_Antarctic_lichen_i_Umbilicaria_antarctica_i_as_tau_protein_inhibitor/7294418/1 unknown Taylor & Francis https://dx.doi.org/10.1080/14786419.2018.1492576 https://dx.doi.org/10.6084/m9.figshare.7294418 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Biophysics Biochemistry Molecular Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Inorganic Chemistry Text article-journal Journal contribution ScholarlyArticle 2018 ftdatacite https://doi.org/10.6084/m9.figshare.7294418.v1 https://doi.org/10.1080/14786419.2018.1492576 https://doi.org/10.6084/m9.figshare.7294418 2021-11-05T12:55:41Z Alzheimer´s disease (AD) is the most common form of dementia involving Aβ and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100 µM. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide 306 VQIVYK 311 were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from 306 VQIVYK 311 motif. Text Antarc* Antarctic Antarctica DataCite Metadata Store (German National Library of Science and Technology) Antarctic The Antarctic |
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unknown |
topic |
Biophysics Biochemistry Molecular Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Inorganic Chemistry |
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Biophysics Biochemistry Molecular Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Inorganic Chemistry Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
topic_facet |
Biophysics Biochemistry Molecular Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Inorganic Chemistry |
description |
Alzheimer´s disease (AD) is the most common form of dementia involving Aβ and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100 µM. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide 306 VQIVYK 311 were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from 306 VQIVYK 311 motif. |
format |
Text |
author |
Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos |
author_facet |
Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos |
author_sort |
Salgado, Francisco |
title |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_short |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_full |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_fullStr |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_full_unstemmed |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_sort |
continental and antarctic lichens: isolation, identification and molecular modeling of the depside tenuiorin from the antarctic lichen umbilicaria antarctica as tau protein inhibitor |
publisher |
Taylor & Francis |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.7294418.v1 https://tandf.figshare.com/articles/Continental_and_Antarctic_Lichens_isolation_identification_and_molecular_modeling_of_the_depside_tenuiorin_from_the_Antarctic_lichen_i_Umbilicaria_antarctica_i_as_tau_protein_inhibitor/7294418/1 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
https://dx.doi.org/10.1080/14786419.2018.1492576 https://dx.doi.org/10.6084/m9.figshare.7294418 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.7294418.v1 https://doi.org/10.1080/14786419.2018.1492576 https://doi.org/10.6084/m9.figshare.7294418 |
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