Bioactive metabolites from the Arctic fungus Nectria sp. B-13

• Main Authors: Yu, Hao-Bing, Jiao, Heng, Zhu, Yu-Ping, Zhang, Jian-Peng, Lu, Xiao-Ling, Liu, Xiao-Yu
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2018
• Subjects: Biochemistry; Medicine; Microbiology; FOS Biological sciences; Pharmacology; Biotechnology; 59999 Environmental Sciences not elsewhere classified; FOS Earth and related environmental sciences; 39999 Chemical Sciences not elsewhere classified; FOS Chemical sciences; Ecology; 69999 Biological Sciences not elsewhere classified; Cancer; Hematology; Arctic
• Online Access: https://dx.doi.org/10.6084/m9.figshare.6586820.v1; https://tandf.figshare.com/articles/Bioactive_metabolites_from_the_Arctic_fungus_i_Nectria_i_sp_B-13/6586820/1

Two new cyclohexanone derivatives, nectriatones A–B ( 1 – 2 ), and one new natural product, nectriatone C ( 3 ), together with three known phenolic sesquiterpene derivatives ( 4 – 6 ), were isolated from the culture of Nectria sp. B-13 obtained from high-latitude soil of the Arctic. The structures of all compounds were unambiguously elucidated by extensive spectroscopic analysis, as well as by comparison with the literature. These compounds were evaluated in cytotoxic and antibacterial activities. Compounds 1 – 6 showed cytotoxicities against SW1990, HCT-116, MCF-7, and K562 cells, with IC 50 values in the range of 0.43 to 42.64 μM. Only compound 4 exhibited antibacterial activity against Escherichisa coli , Bacillus subtilis , and Staphylococcus aureus (MIC 4.0, 2.0, and 4.0 μg/ml, respectively).