Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ...
Novel amphiphilic triblock copolymers poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) (PTE- b -PEG- b -PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These BAB-type triblock copolymers wer...
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2018
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.6465074 https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_pH-responsive_poly_i_i_-thioether_ester_-_i_b_i_-poly_ethylene_glycol_-_i_b_i_-poly_i_i_-thioether_ester_amphiphilic_triblock_copolymers_for_drug_delivery/6465074 |
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ftdatacite:10.6084/m9.figshare.6465074 2024-03-31T07:48:16+00:00 Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... Wu, Wan-Xia Yang, Xian-Ling Wang, Xiong Zhang, Yin Li, Han-Mei Lan, Li Deng, Jie Wang, Na Yu, Xiao-Qi 2018 https://dx.doi.org/10.6084/m9.figshare.6465074 https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_pH-responsive_poly_i_i_-thioether_ester_-_i_b_i_-poly_ethylene_glycol_-_i_b_i_-poly_i_i_-thioether_ester_amphiphilic_triblock_copolymers_for_drug_delivery/6465074 unknown Taylor & Francis https://dx.doi.org/10.1080/00914037.2018.1473864 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Biophysics Biochemistry Space Science Medicine Pharmacology Biotechnology Chemical Sciences not elsewhere classified Text Journal contribution article-journal ScholarlyArticle 2018 ftdatacite https://doi.org/10.6084/m9.figshare.646507410.1080/00914037.2018.1473864 2024-03-04T13:08:03Z Novel amphiphilic triblock copolymers poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) (PTE- b -PEG- b -PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These BAB-type triblock copolymers were synthesized via one-step enzymatic polycondensation with catalysis by immobilized lipase B from Candida antarctica (CALB). The copolymers could self-assemble to form flower-like nanosized micelles in aqueous solution. The pH-triggered disassembly behaviors of the micelles were evaluated from the changes of the micellar size and molecular weight due to the acid-degradable β -thiopropionate groups in the hydrophobic PTE core. Cur was encapsulated into the micelles and showed faster release at pH 5.0 than pH 7.4. In vitro experiments indicated that the copolymers were non-cytotoxic, while the Cur-loaded micelles effectively inhibited the proliferation of HeLa cells. All these findings demonstrated the potential of ... Text Antarc* Antarctica DataCite Metadata Store (German National Library of Science and Technology) |
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Biophysics Biochemistry Space Science Medicine Pharmacology Biotechnology Chemical Sciences not elsewhere classified |
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Biophysics Biochemistry Space Science Medicine Pharmacology Biotechnology Chemical Sciences not elsewhere classified Wu, Wan-Xia Yang, Xian-Ling Wang, Xiong Zhang, Yin Li, Han-Mei Lan, Li Deng, Jie Wang, Na Yu, Xiao-Qi Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
topic_facet |
Biophysics Biochemistry Space Science Medicine Pharmacology Biotechnology Chemical Sciences not elsewhere classified |
description |
Novel amphiphilic triblock copolymers poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) (PTE- b -PEG- b -PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These BAB-type triblock copolymers were synthesized via one-step enzymatic polycondensation with catalysis by immobilized lipase B from Candida antarctica (CALB). The copolymers could self-assemble to form flower-like nanosized micelles in aqueous solution. The pH-triggered disassembly behaviors of the micelles were evaluated from the changes of the micellar size and molecular weight due to the acid-degradable β -thiopropionate groups in the hydrophobic PTE core. Cur was encapsulated into the micelles and showed faster release at pH 5.0 than pH 7.4. In vitro experiments indicated that the copolymers were non-cytotoxic, while the Cur-loaded micelles effectively inhibited the proliferation of HeLa cells. All these findings demonstrated the potential of ... |
format |
Text |
author |
Wu, Wan-Xia Yang, Xian-Ling Wang, Xiong Zhang, Yin Li, Han-Mei Lan, Li Deng, Jie Wang, Na Yu, Xiao-Qi |
author_facet |
Wu, Wan-Xia Yang, Xian-Ling Wang, Xiong Zhang, Yin Li, Han-Mei Lan, Li Deng, Jie Wang, Na Yu, Xiao-Qi |
author_sort |
Wu, Wan-Xia |
title |
Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
title_short |
Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
title_full |
Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
title_fullStr |
Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
title_full_unstemmed |
Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
title_sort |
lipase-catalyzed synthesis of ph-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ... |
publisher |
Taylor & Francis |
publishDate |
2018 |
url |
https://dx.doi.org/10.6084/m9.figshare.6465074 https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_pH-responsive_poly_i_i_-thioether_ester_-_i_b_i_-poly_ethylene_glycol_-_i_b_i_-poly_i_i_-thioether_ester_amphiphilic_triblock_copolymers_for_drug_delivery/6465074 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://dx.doi.org/10.1080/00914037.2018.1473864 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.6084/m9.figshare.646507410.1080/00914037.2018.1473864 |
_version_ |
1795030163024510976 |