Lipase-catalyzed synthesis of pH-responsive poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) amphiphilic triblock copolymers for drug delivery ...
Novel amphiphilic triblock copolymers poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) (PTE- b -PEG- b -PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These BAB-type triblock copolymers wer...
Main Authors: | , , , , , , , , |
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Format: | Text |
Language: | unknown |
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Taylor & Francis
2018
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.6465074 https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_pH-responsive_poly_i_i_-thioether_ester_-_i_b_i_-poly_ethylene_glycol_-_i_b_i_-poly_i_i_-thioether_ester_amphiphilic_triblock_copolymers_for_drug_delivery/6465074 |
Summary: | Novel amphiphilic triblock copolymers poly( β -thioether ester)- b -poly(ethylene glycol)- b -poly( β -thioether ester) (PTE- b -PEG- b -PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These BAB-type triblock copolymers were synthesized via one-step enzymatic polycondensation with catalysis by immobilized lipase B from Candida antarctica (CALB). The copolymers could self-assemble to form flower-like nanosized micelles in aqueous solution. The pH-triggered disassembly behaviors of the micelles were evaluated from the changes of the micellar size and molecular weight due to the acid-degradable β -thiopropionate groups in the hydrophobic PTE core. Cur was encapsulated into the micelles and showed faster release at pH 5.0 than pH 7.4. In vitro experiments indicated that the copolymers were non-cytotoxic, while the Cur-loaded micelles effectively inhibited the proliferation of HeLa cells. All these findings demonstrated the potential of ... |
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