Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

A new polyene compound ( 1 ) and a new diketopiperazine ( 2 ), as well as three known compounds ( 3 – 5 ), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1 – 5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. Th...

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Bibliographic Details
Main Authors: Cong-Cong Liu, Zhang, Zhen-Zhen, Feng, Yan-Yan, Qian-Qun Gu, Li, De-Hai, Zhu, Tian-Jiao
Format: Text
Language:unknown
Published: Taylor & Francis 2018
Subjects:
Biochemistry
Microbiology
FOS Biological sciences
Neuroscience
Pharmacology
59999 Environmental Sciences not elsewhere classified
FOS Earth and related environmental sciences
39999 Chemical Sciences not elsewhere classified
FOS Chemical sciences
Ecology
Inorganic Chemistry
Plant Biology
60506 Virology
Antarctic
The Antarctic
Antarc*
Online Access:https://dx.doi.org/10.6084/m9.figshare.6067418.v1
https://tandf.figshare.com/articles/Secondary_metabolites_from_Antarctic_marine-derived_fungus_i_Penicillium_crustosum_i_HDN153086/6067418/1
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Summary:A new polyene compound ( 1 ) and a new diketopiperazine ( 2 ), as well as three known compounds ( 3 – 5 ), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1 – 5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC 50 value of 12.7 μM.

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