Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association...
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The Royal Society
2017
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ftdatacite:10.6084/m9.figshare.5705809.v1 2023-05-15T15:34:41+02:00 Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. 2017 https://dx.doi.org/10.6084/m9.figshare.5705809.v1 https://rs.figshare.com/articles/Data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705809/1 unknown The Royal Society https://dx.doi.org/10.1098/rstb.2016.0447 https://dx.doi.org/10.6084/m9.figshare.5705809 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Evolutionary Biology FOS Biological sciences Ecology dataset Dataset 2017 ftdatacite https://doi.org/10.6084/m9.figshare.5705809.v1 https://doi.org/10.1098/rstb.2016.0447 https://doi.org/10.6084/m9.figshare.5705809 2021-11-05T12:55:41Z Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. Dataset Avian Studies DataCite Metadata Store (German National Library of Science and Technology) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
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topic |
Evolutionary Biology FOS Biological sciences Ecology |
spellingShingle |
Evolutionary Biology FOS Biological sciences Ecology Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
topic_facet |
Evolutionary Biology FOS Biological sciences Ecology |
description |
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. |
format |
Dataset |
author |
Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. |
author_facet |
Wilbourn, Rachael V. Moatt, Joshua P. Froy, Hannah Walling, Craig A. Nussey, Daniel H. Boonekamp, Jelle J. |
author_sort |
Wilbourn, Rachael V. |
title |
Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_short |
Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_full |
Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_fullStr |
Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_full_unstemmed |
Data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_sort |
data from the relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
publisher |
The Royal Society |
publishDate |
2017 |
url |
https://dx.doi.org/10.6084/m9.figshare.5705809.v1 https://rs.figshare.com/articles/Data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705809/1 |
genre |
Avian Studies |
genre_facet |
Avian Studies |
op_relation |
https://dx.doi.org/10.1098/rstb.2016.0447 https://dx.doi.org/10.6084/m9.figshare.5705809 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.5705809.v1 https://doi.org/10.1098/rstb.2016.0447 https://doi.org/10.6084/m9.figshare.5705809 |
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