Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18 ...
A new furanone derivative, butanolide A ( 1 ), and a new sesquiterpene, guignarderemophilane F ( 2 ), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-...
Main Authors: | , , , , , |
---|---|
Format: | Text |
Language: | unknown |
Published: |
Taylor & Francis
2017
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.5481388 https://tandf.figshare.com/articles/journal_contribution/Furanone_derivative_and_sesquiterpene_from_Antarctic_marine-derived_fungus_i_Penicillium_i_sp_S-1-18/5481388 |
Summary: | A new furanone derivative, butanolide A ( 1 ), and a new sesquiterpene, guignarderemophilane F ( 2 ), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher’s method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC 50 value of 27.4 μM. ... |
---|