Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have in...
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2015
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ftdatacite:10.6084/m9.figshare.5128849 2023-05-15T18:34:48+02:00 Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population Eriksen, B.O. Løchen, M.-L. Arntzen, K.A. Bertelsen, G. Winther Eilertsen, B.-A. Von Hanno, T. Herder, M. Jenssen, T.G. Mathisen, U.D. Melsom, T. 2015 https://dx.doi.org/10.6084/m9.figshare.5128849 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Estimated_and_Measured_GFR_Associate_Differently_with_Retinal_Vasculopathy_in_the_General_Population/5128849 unknown Karger Publishers https://dx.doi.org/10.1159/000441092 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine dataset Dataset 2015 ftdatacite https://doi.org/10.6084/m9.figshare.5128849 https://doi.org/10.1159/000441092 2021-11-05T12:55:41Z Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons. Dataset Tromsø DataCite Metadata Store (German National Library of Science and Technology) Tromsø |
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DataCite Metadata Store (German National Library of Science and Technology) |
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Medicine Eriksen, B.O. Løchen, M.-L. Arntzen, K.A. Bertelsen, G. Winther Eilertsen, B.-A. Von Hanno, T. Herder, M. Jenssen, T.G. Mathisen, U.D. Melsom, T. Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
topic_facet |
Medicine |
description |
Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFR cys ) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFR crea ) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons. |
format |
Dataset |
author |
Eriksen, B.O. Løchen, M.-L. Arntzen, K.A. Bertelsen, G. Winther Eilertsen, B.-A. Von Hanno, T. Herder, M. Jenssen, T.G. Mathisen, U.D. Melsom, T. |
author_facet |
Eriksen, B.O. Løchen, M.-L. Arntzen, K.A. Bertelsen, G. Winther Eilertsen, B.-A. Von Hanno, T. Herder, M. Jenssen, T.G. Mathisen, U.D. Melsom, T. |
author_sort |
Eriksen, B.O. |
title |
Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_short |
Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_full |
Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_fullStr |
Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_full_unstemmed |
Supplementary Material for: Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population |
title_sort |
supplementary material for: estimated and measured gfr associate differently with retinal vasculopathy in the general population |
publisher |
Karger Publishers |
publishDate |
2015 |
url |
https://dx.doi.org/10.6084/m9.figshare.5128849 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Estimated_and_Measured_GFR_Associate_Differently_with_Retinal_Vasculopathy_in_the_General_Population/5128849 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://dx.doi.org/10.1159/000441092 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.5128849 https://doi.org/10.1159/000441092 |
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1766219720043790336 |