Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting
Background: Bilirubin, an antioxidant, has been associated with reduced cardiovascular disease risk. A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription b...
Main Authors: | , , , , , , , |
---|---|
Format: | Dataset |
Language: | unknown |
Published: |
Karger Publishers
2010
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.5121373 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Bilirubin_and_UGT1A1_28_Are_Not_Associated_with_Lower_Risk_for_Ischemic_Stroke_in_a_Prospective_Nested_Case-Referent_Setting/5121373 |
id |
ftdatacite:10.6084/m9.figshare.5121373 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.5121373 2023-05-15T17:44:46+02:00 Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting Ekblom, K. Marklund, S.L. Johansson, L. Osterman, P. Hallmans, G. Weinehall, L. Wiklund, P.-G. Hultdin, J. 2010 https://dx.doi.org/10.6084/m9.figshare.5121373 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Bilirubin_and_UGT1A1_28_Are_Not_Associated_with_Lower_Risk_for_Ischemic_Stroke_in_a_Prospective_Nested_Case-Referent_Setting/5121373 unknown Karger Publishers https://dx.doi.org/10.1159/000319778 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine dataset Dataset 2010 ftdatacite https://doi.org/10.6084/m9.figshare.5121373 https://doi.org/10.1159/000319778 2021-11-05T12:55:41Z Background: Bilirubin, an antioxidant, has been associated with reduced cardiovascular disease risk. A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%. Earlier studies reporting a protective effect of bilirubin on stroke have not included analysis of UGT1A1*28. The purpose of this study is to investigate if bilirubin and UGT1A1*28 are protective against ischemic stroke in a prospective case-referent setting. Methods: Cases with first-ever ischemic stroke (n = 231; median lag time 4.9 years) and 462 matched referents from the Northern Sweden Health and Disease Study Cohort were included. Plasma bilirubin was measured and UGT1A1*28 was analyzed by fragment analysis. Results: Plasma bilirubin was lower in cases than in referents, but the difference reached significance only for women. The UGT1A1*28 polymorphism (allele frequency 30%) showed a strong gene-dose relationship with bilirubin levels both among cases and referents, but was not associated with risk for stroke. Among multiple other variables analyzed, the strongest correlation with bilirubin was found for plasma iron. Conclusions: There was no evidence for a protective effect of the UGT1A1*28 polymorphism against stroke and consequently neither for bilirubin. The findings suggest that other factors influencing the risk for stroke might also affect bilirubin levels. Dataset Northern Sweden DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine |
spellingShingle |
Medicine Ekblom, K. Marklund, S.L. Johansson, L. Osterman, P. Hallmans, G. Weinehall, L. Wiklund, P.-G. Hultdin, J. Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
topic_facet |
Medicine |
description |
Background: Bilirubin, an antioxidant, has been associated with reduced cardiovascular disease risk. A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%. Earlier studies reporting a protective effect of bilirubin on stroke have not included analysis of UGT1A1*28. The purpose of this study is to investigate if bilirubin and UGT1A1*28 are protective against ischemic stroke in a prospective case-referent setting. Methods: Cases with first-ever ischemic stroke (n = 231; median lag time 4.9 years) and 462 matched referents from the Northern Sweden Health and Disease Study Cohort were included. Plasma bilirubin was measured and UGT1A1*28 was analyzed by fragment analysis. Results: Plasma bilirubin was lower in cases than in referents, but the difference reached significance only for women. The UGT1A1*28 polymorphism (allele frequency 30%) showed a strong gene-dose relationship with bilirubin levels both among cases and referents, but was not associated with risk for stroke. Among multiple other variables analyzed, the strongest correlation with bilirubin was found for plasma iron. Conclusions: There was no evidence for a protective effect of the UGT1A1*28 polymorphism against stroke and consequently neither for bilirubin. The findings suggest that other factors influencing the risk for stroke might also affect bilirubin levels. |
format |
Dataset |
author |
Ekblom, K. Marklund, S.L. Johansson, L. Osterman, P. Hallmans, G. Weinehall, L. Wiklund, P.-G. Hultdin, J. |
author_facet |
Ekblom, K. Marklund, S.L. Johansson, L. Osterman, P. Hallmans, G. Weinehall, L. Wiklund, P.-G. Hultdin, J. |
author_sort |
Ekblom, K. |
title |
Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
title_short |
Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
title_full |
Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
title_fullStr |
Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
title_full_unstemmed |
Supplementary Material for: Bilirubin and UGT1A1*28 Are Not Associated with Lower Risk for Ischemic Stroke in a Prospective Nested Case-Referent Setting |
title_sort |
supplementary material for: bilirubin and ugt1a1*28 are not associated with lower risk for ischemic stroke in a prospective nested case-referent setting |
publisher |
Karger Publishers |
publishDate |
2010 |
url |
https://dx.doi.org/10.6084/m9.figshare.5121373 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Bilirubin_and_UGT1A1_28_Are_Not_Associated_with_Lower_Risk_for_Ischemic_Stroke_in_a_Prospective_Nested_Case-Referent_Setting/5121373 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://dx.doi.org/10.1159/000319778 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.5121373 https://doi.org/10.1159/000319778 |
_version_ |
1766147056578068480 |