Antibacterial constituents from Antarctic fungus, Aspergillus sydowii SP-1 ...

• Main Authors: Li, Wen-ting, Luo, Dan, Huang, Jia-ning, Wang, Lin-lin, Zhang, Feng-guo, Xi, Tao, Liao, Jian-min, Lu, Yuan-yuan
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2017
• Subjects: Biochemistry; Medicine; Microbiology; FOS Biological sciences; Pharmacology; Environmental Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Hematology; Infectious Diseases; FOS Health sciences; Antarc*; Antarctic
• Online Access: https://dx.doi.org/10.6084/m9.figshare.5100157; https://tandf.figshare.com/articles/journal_contribution/Antibacterial_constituents_from_Antarctic_fungus_i_Aspergillus_sydowii_i_SP-1/5100157/1

One new alkaloid, named as acremolin C ( 1 ), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo -( L -Trp- L -Phe) ( 2 ), 4-hydroxyphenylacetic acid ( 3 ), (7 S )-(+)-hydroxysydonic acid ( 4 ) and (7 S , 11 S )-(+)-12-hydroxysydonic acid ( 5 ), were isolated and identified. Biological studies disclosed that compounds 2 , 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE. ...