Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer
Objective: Approximately 20–30% of all colorectal cancer (CRC) cases may have a familial contribution. The family history of CRC can be prominent (e.g., hereditary colorectal cancer (HCRC)) or more moderate (e.g., familial colorectal cancer (FCRC)). For family members at risk, colonoscopic surveilla...
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ftdatacite:10.6084/m9.figshare.5085652.v1 2023-05-15T17:44:58+02:00 Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer Sjöström, Olle Lindholm, Lars Melin, Beatrice 2017 https://dx.doi.org/10.6084/m9.figshare.5085652.v1 https://tandf.figshare.com/articles/journal_contribution/Colonoscopic_surveillance_a_cost-effective_method_to_prevent_hereditary_and_familial_colorectal_cancer/5085652/1 unknown Taylor & Francis https://dx.doi.org/10.1080/00365521.2017.1327615 https://dx.doi.org/10.6084/m9.figshare.5085652 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine Pharmacology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Computational Biology Text article-journal Journal contribution ScholarlyArticle 2017 ftdatacite https://doi.org/10.6084/m9.figshare.5085652.v1 https://doi.org/10.1080/00365521.2017.1327615 https://doi.org/10.6084/m9.figshare.5085652 2021-11-05T12:55:41Z Objective: Approximately 20–30% of all colorectal cancer (CRC) cases may have a familial contribution. The family history of CRC can be prominent (e.g., hereditary colorectal cancer (HCRC)) or more moderate (e.g., familial colorectal cancer (FCRC)). For family members at risk, colonoscopic surveillance is a well-established method to prevent both HCRC and FCRC, although the evidence for the exact procedures of the surveillance is limited. Surveillance can come at a high price if individuals are frequently examined, as this may result in unnecessary colonoscopies in relation to actual risk for CRC. This study analyses the cost-effectiveness of a surveillance programme implemented in the Northern Sweden Health Care Region. Methods: The study includes 259 individuals prospectively recorded in the colonoscopic surveillance programme registry at the Cancer Prevention Clinic, Umeå University Hospital. We performed a cost–utility analysis with a contrafactual design: we compared observed costs and loss of quality-adjusted life years (QALYs) due to CRC with the surveillance programme to an expected outcome without surveillance. The main measure was the incremental cost-effectiveness ratio (ICER) between surveillance and non-surveillance. Scenario analysis was used to explore uncertainty. Results: The ICER between surveillance and non-surveillance in the base model was 3596€/QALY. The ICER varied from −4620€ in the best-case scenario to 33,779€ in the worst-case scenario. Conclusion: Colonoscopic surveillance is a very cost-effective method to prevent HCRC and FCRC compared to current thresholds for cost-effectiveness and other cancer preventive interventions. Text Northern Sweden DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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Medicine Pharmacology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Computational Biology |
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Medicine Pharmacology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Computational Biology Sjöström, Olle Lindholm, Lars Melin, Beatrice Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
topic_facet |
Medicine Pharmacology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Sociology FOS Sociology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Computational Biology |
description |
Objective: Approximately 20–30% of all colorectal cancer (CRC) cases may have a familial contribution. The family history of CRC can be prominent (e.g., hereditary colorectal cancer (HCRC)) or more moderate (e.g., familial colorectal cancer (FCRC)). For family members at risk, colonoscopic surveillance is a well-established method to prevent both HCRC and FCRC, although the evidence for the exact procedures of the surveillance is limited. Surveillance can come at a high price if individuals are frequently examined, as this may result in unnecessary colonoscopies in relation to actual risk for CRC. This study analyses the cost-effectiveness of a surveillance programme implemented in the Northern Sweden Health Care Region. Methods: The study includes 259 individuals prospectively recorded in the colonoscopic surveillance programme registry at the Cancer Prevention Clinic, Umeå University Hospital. We performed a cost–utility analysis with a contrafactual design: we compared observed costs and loss of quality-adjusted life years (QALYs) due to CRC with the surveillance programme to an expected outcome without surveillance. The main measure was the incremental cost-effectiveness ratio (ICER) between surveillance and non-surveillance. Scenario analysis was used to explore uncertainty. Results: The ICER between surveillance and non-surveillance in the base model was 3596€/QALY. The ICER varied from −4620€ in the best-case scenario to 33,779€ in the worst-case scenario. Conclusion: Colonoscopic surveillance is a very cost-effective method to prevent HCRC and FCRC compared to current thresholds for cost-effectiveness and other cancer preventive interventions. |
format |
Text |
author |
Sjöström, Olle Lindholm, Lars Melin, Beatrice |
author_facet |
Sjöström, Olle Lindholm, Lars Melin, Beatrice |
author_sort |
Sjöström, Olle |
title |
Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
title_short |
Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
title_full |
Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
title_fullStr |
Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
title_full_unstemmed |
Colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
title_sort |
colonoscopic surveillance – a cost-effective method to prevent hereditary and familial colorectal cancer |
publisher |
Taylor & Francis |
publishDate |
2017 |
url |
https://dx.doi.org/10.6084/m9.figshare.5085652.v1 https://tandf.figshare.com/articles/journal_contribution/Colonoscopic_surveillance_a_cost-effective_method_to_prevent_hereditary_and_familial_colorectal_cancer/5085652/1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://dx.doi.org/10.1080/00365521.2017.1327615 https://dx.doi.org/10.6084/m9.figshare.5085652 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.5085652.v1 https://doi.org/10.1080/00365521.2017.1327615 https://doi.org/10.6084/m9.figshare.5085652 |
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1766147656529215488 |