Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ...
Tyrosol is a principle phenolic compound present in olive oil and wine with great pharmacological potentials due to its strong antioxidant property. Its application can be highly extended by increasing its lipophilicity through esterification. In this study, tyrosol esters were synthesized by enzyma...
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Taylor & Francis
2024
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ftdatacite:10.6084/m9.figshare.25145048.v1 2024-09-15T17:46:34+00:00 Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... Wang, Kang-Hong Li, Shuangfei Meng, Ying-Fen Zou, Yong Liang, Guo-Bin Yang, Cheng Yang, Zhen 2024 https://dx.doi.org/10.6084/m9.figshare.25145048.v1 https://tandf.figshare.com/articles/journal_contribution/Enzymatic_synthesis_of_tyrosol_esters_in_organic_solvents_and_ionic_liquids_Correlation_between_enzyme_activity_and_solvent_properties/25145048/1 unknown Taylor & Francis https://dx.doi.org/10.6084/m9.figshare.25145048 https://dx.doi.org/10.1080/10242422.2024.2312977 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Biophysics Biochemistry Microbiology FOS Biological sciences Genetics Pharmacology Biotechnology Chemical Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Plant Biology Text Journal contribution ScholarlyArticle article-journal 2024 ftdatacite https://doi.org/10.6084/m9.figshare.25145048.v110.6084/m9.figshare.2514504810.1080/10242422.2024.2312977 2024-08-01T10:12:38Z Tyrosol is a principle phenolic compound present in olive oil and wine with great pharmacological potentials due to its strong antioxidant property. Its application can be highly extended by increasing its lipophilicity through esterification. In this study, tyrosol esters were synthesized by enzymatic transesterification of tyrosol with vinyl esters, with a commercial lipase from Novozymes (Novozym 435, Candida antarctica lipase B (CALB) immobilized on macroporous acrylic resin beads) as the catalyst, both in organic solvents and in ionic liquids. Methyl tert -butyl ether (MTBE) was the best solvent, offering complete conversions towards the synthesis of tyrosol esters with varying chain lengths (C2-C18) within 1 h. Taking the enzymatic transesterification between tyrosol and vinyl acetate as the model reaction, 18 organic solvents and 24 ionic liquids were screened, and their solvent properties (i.e. hydrophobicity, polarity, viscosity, water activity, and partition coefficients of substrate and product) ... Text Antarc* Antarctica DataCite |
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Biophysics Biochemistry Microbiology FOS Biological sciences Genetics Pharmacology Biotechnology Chemical Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Plant Biology |
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Biophysics Biochemistry Microbiology FOS Biological sciences Genetics Pharmacology Biotechnology Chemical Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Plant Biology Wang, Kang-Hong Li, Shuangfei Meng, Ying-Fen Zou, Yong Liang, Guo-Bin Yang, Cheng Yang, Zhen Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
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Biophysics Biochemistry Microbiology FOS Biological sciences Genetics Pharmacology Biotechnology Chemical Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Plant Biology |
description |
Tyrosol is a principle phenolic compound present in olive oil and wine with great pharmacological potentials due to its strong antioxidant property. Its application can be highly extended by increasing its lipophilicity through esterification. In this study, tyrosol esters were synthesized by enzymatic transesterification of tyrosol with vinyl esters, with a commercial lipase from Novozymes (Novozym 435, Candida antarctica lipase B (CALB) immobilized on macroporous acrylic resin beads) as the catalyst, both in organic solvents and in ionic liquids. Methyl tert -butyl ether (MTBE) was the best solvent, offering complete conversions towards the synthesis of tyrosol esters with varying chain lengths (C2-C18) within 1 h. Taking the enzymatic transesterification between tyrosol and vinyl acetate as the model reaction, 18 organic solvents and 24 ionic liquids were screened, and their solvent properties (i.e. hydrophobicity, polarity, viscosity, water activity, and partition coefficients of substrate and product) ... |
format |
Text |
author |
Wang, Kang-Hong Li, Shuangfei Meng, Ying-Fen Zou, Yong Liang, Guo-Bin Yang, Cheng Yang, Zhen |
author_facet |
Wang, Kang-Hong Li, Shuangfei Meng, Ying-Fen Zou, Yong Liang, Guo-Bin Yang, Cheng Yang, Zhen |
author_sort |
Wang, Kang-Hong |
title |
Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
title_short |
Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
title_full |
Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
title_fullStr |
Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
title_full_unstemmed |
Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties ... |
title_sort |
enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: correlation between enzyme activity and solvent properties ... |
publisher |
Taylor & Francis |
publishDate |
2024 |
url |
https://dx.doi.org/10.6084/m9.figshare.25145048.v1 https://tandf.figshare.com/articles/journal_contribution/Enzymatic_synthesis_of_tyrosol_esters_in_organic_solvents_and_ionic_liquids_Correlation_between_enzyme_activity_and_solvent_properties/25145048/1 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://dx.doi.org/10.6084/m9.figshare.25145048 https://dx.doi.org/10.1080/10242422.2024.2312977 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.6084/m9.figshare.25145048.v110.6084/m9.figshare.2514504810.1080/10242422.2024.2312977 |
_version_ |
1810494830131806208 |