Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts ...

• Main Authors: Garvey, Gregory J., Anderson, Janet K., Goodrum, Philip E., Tyndall, Kirby H., Cox, L. Anthony, Khatami, Mahin, Morales-Montor, Jorge, Schoeny, Rita S., Seed, Jennifer G., Tyagi, Rajeev K., Kirman, Christopher R., Hays, Sean M.
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: Taylor & Francis 2023
• Subjects: Biochemistry; Medicine; 59999 Environmental Sciences not elsewhere classified; FOS Earth and related environmental sciences; 39999 Chemical Sciences not elsewhere classified; FOS Chemical sciences; Immunology; FOS Clinical medicine; Cancer; Science Policy; Hematology; 110309 Infectious Diseases; FOS Health sciences; Faroe Islands
• Online Access: https://dx.doi.org/10.6084/m9.figshare.22718744.v1; https://tandf.figshare.com/articles/journal_contribution/Weight_of_evidence_evaluation_for_chemical-induced_immunotoxicity_for_PFOA_and_PFOS_findings_from_an_independent_panel_of_experts/22718744/1

Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl substances (PFAS) causes immune dysregulation is subject to much debate. An independent, international expert panel was engaged utilizing methods to reduce bias and “groupthink”. The panel concluded there is moderate evidence that PFOS and PFOA are immunotoxic, based primarily on evidence from animal data. However, species concordance and human relevance cannot be well established due to data limitations. The panel recommended additional testing that includes longer-term exposures, evaluates both genders, includes other species of animals, tests lower dose levels, assesses more complete measures of immune responses, and elucidates the mechanism of action. Panel members agreed that the Faroe Islands cohort data should not be used as the primary basis for deriving ...