Malignancy rates of salivary gland tumors in Greenlandic Inuit comparable to non-endemic populations; epidemiological mapping of salivary gland tumors 1990–2019 ...

• Main Authors: Haugaard, Carl Frederik, Andreasen, Simon, Eriksen, Patrick R. G., Olsen, Caroline, Kiss, Katalin, Bjørndal, Kristine, Westergaard-Nielsen, Marie, Homøe, Preben
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2023
• Subjects: Biotechnology; Cancer; greenlandic; inuit
• Online Access: https://dx.doi.org/10.6084/m9.figshare.22325495; https://tandf.figshare.com/articles/journal_contribution/Malignancy_rates_of_salivary_gland_tumors_in_Greenlandic_Inuit_comparable_to_non-endemic_populations_epidemiological_mapping_of_salivary_gland_tumors_1990_2019/22325495

Salivary gland tumors are assumed to be predominantly malignant in the Greenlandic Inuit population, but there is limited literature on the subject. We conducted a retrospective cohort study using national registers to describe the histological tumor types, location, incidence, and survival of benign and malignant salivary gland tumors. We analyzed data on all Greenlandic Inuit with an epithelial-derived salivary gland tumor from 1990 to 2019. We extracted data from the Central Personal Registry and crossmatched it with the Danish Pathology Data Bank. All specimens were reviewed by a specialized pathologist. We noted patient and histological characteristics, calculated crude and age-adjusted incidence rates, overall survival, and excess mortality. Our study found that 76% of salivary gland tumors in the Greenlandic Inuit population were benign, with pleomorphic adenoma being the most common. Malignant tumors accounted for 24% of cases, with lymphoepithelial carcinoma being the most common type. The most ...