Fig. 3 | SIAS Analysis of NPC1 N Terminus Domain Amongst Varying Mammal Species

• Main Authors: Oh, Jonathan, Bedru, Eldana, Yang, Davin
• Format: Still Image
• Language: unknown
• Published: figshare 2022
• Subjects: 60804 Animal Immunology; FOS Biological sciences; Canis lupus
• Online Access: https://dx.doi.org/10.6084/m9.figshare.19349825; https://figshare.com/articles/figure/Fig_3_SIAS_Analysis_of_NPC1_N_Terminus_Domain_Amongst_Varying_Mammal_Species/19349825

Fig. 3 | SIAS analysis of NPC1 N Terminus domain including both identity and similarity test. 11 protein sequences were found through Ensembl and inputted into Aliview in order to align and shorten the sequence for only the N terminus domain using MUSCLE. Once the aligned sequence was obtained, the fastfa file was uploaded to a SIAS analysis tool for identity and similarity test. The following species were analyzed: Homo sapien, Pan troglodyte, Gorilla gorilla gorilla, Gallus gallus, Canis lupus familiaris, Bos taurus, Pteropus vampyrus, Rhinopithecus roxellana, Otolemur garnettii, and Rhinolophus ferrumequinum. These tests indicate the level of similarity between differing species with the NPC1 n terminus domain. The identity test indicates the level of 100% same amino acids between two different sequences while the similarity test indicates level of resemblance between two sequences in comparison including side chains.