Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting
The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway. Overall 117 patients were included in this retrospective...
Main Authors: | , , , |
---|---|
Format: | Text |
Language: | unknown |
Published: |
Taylor & Francis
2022
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.19188837 https://tandf.figshare.com/articles/journal_contribution/Feasibility_and_efficacy_of_early_docetaxel_plus_androgen_deprivation_therapy_for_metastatic_hormone-sensitive_prostate_cancer_in_a_rural_health_care_setting/19188837 |
id |
ftdatacite:10.6084/m9.figshare.19188837 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.19188837 2023-05-15T17:24:41+02:00 Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting Nieder, Carsten Stanisavljevic, Luka Dalhaug, Astrid Haukland, Ellinor 2022 https://dx.doi.org/10.6084/m9.figshare.19188837 https://tandf.figshare.com/articles/journal_contribution/Feasibility_and_efficacy_of_early_docetaxel_plus_androgen_deprivation_therapy_for_metastatic_hormone-sensitive_prostate_cancer_in_a_rural_health_care_setting/19188837 unknown Taylor & Francis https://dx.doi.org/10.1080/21681805.2022.2028006 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy article-journal ScholarlyArticle Journal contribution Text 2022 ftdatacite https://doi.org/10.6084/m9.figshare.19188837 https://doi.org/10.1080/21681805.2022.2028006 2022-03-10T13:00:24Z The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway. Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel and androgen deprivation therapy (ADT; the CHAARTED regimen; n = 37), ADT only during the same time period (2014–2020; n = 33), and ADT only in the years 2009–2014 ( n = 47). Four patients (11%) did not complete 6 cycles of docetaxel, one of these due to early progression of cancer. During follow-up, 8 patients (22%) progressed to castration-resistant disease (mCRPC), compared to 24 (73%) with ADT only and 35 (75%) in the historical cohort, p = 0.000001. Such progression occurred within 12 months in 3 patients (8%) treated with docetaxel and 9 patients (27%) treated with ADT only during the same time period, p = 0.05. Median survival was 56 months (95% CI: 40–72 months), compared to 30 months in both other cohorts. 3-year survival rates were 79%, 38% and 37%, respectively ( p = 0.016). In multivariate analysis, the CHAARTED regimen was associated with significantly improved survival. In this rural health care setting, early docetaxel was feasible and effective in reducing progression to mCRPC and prolonging survival. Median survival was very close to the 58 months reported in the CHAARTED trial. Text Nordland Nordland Nordland DataCite Metadata Store (German National Library of Science and Technology) Norway |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Medicine Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy |
spellingShingle |
Medicine Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy Nieder, Carsten Stanisavljevic, Luka Dalhaug, Astrid Haukland, Ellinor Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
topic_facet |
Medicine Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer Science Policy |
description |
The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway. Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel and androgen deprivation therapy (ADT; the CHAARTED regimen; n = 37), ADT only during the same time period (2014–2020; n = 33), and ADT only in the years 2009–2014 ( n = 47). Four patients (11%) did not complete 6 cycles of docetaxel, one of these due to early progression of cancer. During follow-up, 8 patients (22%) progressed to castration-resistant disease (mCRPC), compared to 24 (73%) with ADT only and 35 (75%) in the historical cohort, p = 0.000001. Such progression occurred within 12 months in 3 patients (8%) treated with docetaxel and 9 patients (27%) treated with ADT only during the same time period, p = 0.05. Median survival was 56 months (95% CI: 40–72 months), compared to 30 months in both other cohorts. 3-year survival rates were 79%, 38% and 37%, respectively ( p = 0.016). In multivariate analysis, the CHAARTED regimen was associated with significantly improved survival. In this rural health care setting, early docetaxel was feasible and effective in reducing progression to mCRPC and prolonging survival. Median survival was very close to the 58 months reported in the CHAARTED trial. |
format |
Text |
author |
Nieder, Carsten Stanisavljevic, Luka Dalhaug, Astrid Haukland, Ellinor |
author_facet |
Nieder, Carsten Stanisavljevic, Luka Dalhaug, Astrid Haukland, Ellinor |
author_sort |
Nieder, Carsten |
title |
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
title_short |
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
title_full |
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
title_fullStr |
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
title_full_unstemmed |
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
title_sort |
feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting |
publisher |
Taylor & Francis |
publishDate |
2022 |
url |
https://dx.doi.org/10.6084/m9.figshare.19188837 https://tandf.figshare.com/articles/journal_contribution/Feasibility_and_efficacy_of_early_docetaxel_plus_androgen_deprivation_therapy_for_metastatic_hormone-sensitive_prostate_cancer_in_a_rural_health_care_setting/19188837 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Nordland |
genre_facet |
Nordland Nordland Nordland |
op_relation |
https://dx.doi.org/10.1080/21681805.2022.2028006 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.19188837 https://doi.org/10.1080/21681805.2022.2028006 |
_version_ |
1766115793841422336 |