Lifetime exposure to violence and other life stressors and hair cortisol concentration in women
Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between viole...
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2022
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ftdatacite:10.6084/m9.figshare.18129292.v1 2023-05-15T16:51:44+02:00 Lifetime exposure to violence and other life stressors and hair cortisol concentration in women Lynch, Rebekka Aspelund, Thor Kormáksson, Matthías Flores-Torres, Mario H. Hauksdóttir, Arna Arnberg, Filip K. Lajous, Martín Kirschbaum, Clemens Valdimarsdóttir, Unnur 2022 https://dx.doi.org/10.6084/m9.figshare.18129292.v1 https://tandf.figshare.com/articles/journal_contribution/Lifetime_exposure_to_violence_and_other_life_stressors_and_hair_cortisol_concentration_in_women/18129292/1 unknown Taylor & Francis https://dx.doi.org/10.1080/10253890.2021.2011204 https://dx.doi.org/10.6084/m9.figshare.18129292 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer 111714 Mental Health FOS Health sciences article-journal ScholarlyArticle Journal contribution Text 2022 ftdatacite https://doi.org/10.6084/m9.figshare.18129292.v1 https://doi.org/10.1080/10253890.2021.2011204 https://doi.org/10.6084/m9.figshare.18129292 2022-03-10T14:00:00Z Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between violence and other life stressors and hair cortisol concentration (HCC) in a population of urban women. We included 470 adult women (age = 21–86 years) attending the Cancer Detection Clinic in Iceland. The Life Stressor Checklist-Revised (LSC-R; 30-items) was used to assess exposure. HCC was measured with liquid chromatography coupled with tandem mass spectrometry. We used linear regression models to assess the association between life stressors and log-transformed HCC. The median HCC (pg/mg) in the study population was 4.9 (range 0.6–616.6). HCC was not associated with background covariates, including age ( p = 0.868), education level ( p = 0.824), marital status ( p = 0.545), income ( p = 0.363), occupation ( p = 0.192), but associated with current smoking ( p = 0.013). We noted a 3.3% (95% CI: 0.17–6.6%) associated increase in HCC per endorsed life stressor after adjusting for age and smoking, while non-violent life stressors were not associated with HCC. Per endorsed violence item, we observed a 10.2% (95% CI: 1.4–19.7%) associated increase in HCC after age and smoking adjustment. Women with lifetime exposure to both physical and sexual violence presented with higher HCC than unexposed women ( p = 0.010), after age and smoking adjustment. Lifetime exposure to violence was associated with higher levels of HCC in a community sample of women. These findings need confirmation with prospective studies. Text Iceland DataCite Metadata Store (German National Library of Science and Technology) |
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Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer 111714 Mental Health FOS Health sciences |
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Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer 111714 Mental Health FOS Health sciences Lynch, Rebekka Aspelund, Thor Kormáksson, Matthías Flores-Torres, Mario H. Hauksdóttir, Arna Arnberg, Filip K. Lajous, Martín Kirschbaum, Clemens Valdimarsdóttir, Unnur Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
topic_facet |
Medicine Biotechnology 69999 Biological Sciences not elsewhere classified FOS Biological sciences Cancer 111714 Mental Health FOS Health sciences |
description |
Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between violence and other life stressors and hair cortisol concentration (HCC) in a population of urban women. We included 470 adult women (age = 21–86 years) attending the Cancer Detection Clinic in Iceland. The Life Stressor Checklist-Revised (LSC-R; 30-items) was used to assess exposure. HCC was measured with liquid chromatography coupled with tandem mass spectrometry. We used linear regression models to assess the association between life stressors and log-transformed HCC. The median HCC (pg/mg) in the study population was 4.9 (range 0.6–616.6). HCC was not associated with background covariates, including age ( p = 0.868), education level ( p = 0.824), marital status ( p = 0.545), income ( p = 0.363), occupation ( p = 0.192), but associated with current smoking ( p = 0.013). We noted a 3.3% (95% CI: 0.17–6.6%) associated increase in HCC per endorsed life stressor after adjusting for age and smoking, while non-violent life stressors were not associated with HCC. Per endorsed violence item, we observed a 10.2% (95% CI: 1.4–19.7%) associated increase in HCC after age and smoking adjustment. Women with lifetime exposure to both physical and sexual violence presented with higher HCC than unexposed women ( p = 0.010), after age and smoking adjustment. Lifetime exposure to violence was associated with higher levels of HCC in a community sample of women. These findings need confirmation with prospective studies. |
format |
Text |
author |
Lynch, Rebekka Aspelund, Thor Kormáksson, Matthías Flores-Torres, Mario H. Hauksdóttir, Arna Arnberg, Filip K. Lajous, Martín Kirschbaum, Clemens Valdimarsdóttir, Unnur |
author_facet |
Lynch, Rebekka Aspelund, Thor Kormáksson, Matthías Flores-Torres, Mario H. Hauksdóttir, Arna Arnberg, Filip K. Lajous, Martín Kirschbaum, Clemens Valdimarsdóttir, Unnur |
author_sort |
Lynch, Rebekka |
title |
Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
title_short |
Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
title_full |
Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
title_fullStr |
Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
title_full_unstemmed |
Lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
title_sort |
lifetime exposure to violence and other life stressors and hair cortisol concentration in women |
publisher |
Taylor & Francis |
publishDate |
2022 |
url |
https://dx.doi.org/10.6084/m9.figshare.18129292.v1 https://tandf.figshare.com/articles/journal_contribution/Lifetime_exposure_to_violence_and_other_life_stressors_and_hair_cortisol_concentration_in_women/18129292/1 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://dx.doi.org/10.1080/10253890.2021.2011204 https://dx.doi.org/10.6084/m9.figshare.18129292 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.18129292.v1 https://doi.org/10.1080/10253890.2021.2011204 https://doi.org/10.6084/m9.figshare.18129292 |
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1766041838276313088 |