Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study
Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy. A nationwide study of all GIB events in patients on OACs in Iceland from 2014–2019 w...
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2021
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ftdatacite:10.6084/m9.figshare.16960909.v1 2023-05-15T16:51:18+02:00 Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study Ágústsson, Arnar S. Ingason, Arnar B. Rumba, Edward Pálsson, Daníel Reynisson, Indriði E. Hreinsson, Jóhann P. Björnsson, Einar S. 2021 https://dx.doi.org/10.6084/m9.figshare.16960909.v1 https://tandf.figshare.com/articles/journal_contribution/Causes_of_gastrointestinal_bleeding_in_oral_anticoagulant_users_compared_to_non-users_in_a_population-based_study/16960909/1 unknown Taylor & Francis https://dx.doi.org/10.1080/00365521.2021.1998600 https://dx.doi.org/10.6084/m9.figshare.16960909 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Pharmacology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology FOS Biological sciences Cancer 110309 Infectious Diseases FOS Health sciences ScholarlyArticle article-journal Text Journal contribution 2021 ftdatacite https://doi.org/10.6084/m9.figshare.16960909.v1 https://doi.org/10.1080/00365521.2021.1998600 https://doi.org/10.6084/m9.figshare.16960909 2022-02-09T13:39:26Z Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy. A nationwide study of all GIB events in patients on OACs in Iceland from 2014–2019 was conducted. Bleeding events were obtained through ICD-10 codes and review of endoscopy databases, confirmed by review of medical records. For comparison, patients not on OACs from previous Icelandic population-based studies were used. Among 752 GIB events in 12,005 patients on OACs, 273 (1.9%) had verified upper and 391 (2.7%) had verified lower GIB. For lower GIB, multivariate analysis showed that OAC users were more likely to have colonic polyps (OR 6.6, 95% CI: 2.4 − 17.8, p p p p p = .003) were more common in OAC users. A high proportion of GIB caused by colonic polyps and colorectal cancer among OAC patients indicates that OACs treatment may facilitate cancer diagnosis. The low proportion of ischemic colitis among those on OACs suggests that OACs provide a protective effect against ischemic colitis. OACs seem to increase the bleeding from angiodysplasia and mucosal erosive disease. Other Non-Article Part of Journal/Newspaper Iceland DataCite Metadata Store (German National Library of Science and Technology) |
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collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Pharmacology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology FOS Biological sciences Cancer 110309 Infectious Diseases FOS Health sciences |
spellingShingle |
Pharmacology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology FOS Biological sciences Cancer 110309 Infectious Diseases FOS Health sciences Ágústsson, Arnar S. Ingason, Arnar B. Rumba, Edward Pálsson, Daníel Reynisson, Indriði E. Hreinsson, Jóhann P. Björnsson, Einar S. Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
topic_facet |
Pharmacology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology FOS Biological sciences Cancer 110309 Infectious Diseases FOS Health sciences |
description |
Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy. A nationwide study of all GIB events in patients on OACs in Iceland from 2014–2019 was conducted. Bleeding events were obtained through ICD-10 codes and review of endoscopy databases, confirmed by review of medical records. For comparison, patients not on OACs from previous Icelandic population-based studies were used. Among 752 GIB events in 12,005 patients on OACs, 273 (1.9%) had verified upper and 391 (2.7%) had verified lower GIB. For lower GIB, multivariate analysis showed that OAC users were more likely to have colonic polyps (OR 6.6, 95% CI: 2.4 − 17.8, p p p p p = .003) were more common in OAC users. A high proportion of GIB caused by colonic polyps and colorectal cancer among OAC patients indicates that OACs treatment may facilitate cancer diagnosis. The low proportion of ischemic colitis among those on OACs suggests that OACs provide a protective effect against ischemic colitis. OACs seem to increase the bleeding from angiodysplasia and mucosal erosive disease. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Ágústsson, Arnar S. Ingason, Arnar B. Rumba, Edward Pálsson, Daníel Reynisson, Indriði E. Hreinsson, Jóhann P. Björnsson, Einar S. |
author_facet |
Ágústsson, Arnar S. Ingason, Arnar B. Rumba, Edward Pálsson, Daníel Reynisson, Indriði E. Hreinsson, Jóhann P. Björnsson, Einar S. |
author_sort |
Ágústsson, Arnar S. |
title |
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
title_short |
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
title_full |
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
title_fullStr |
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
title_full_unstemmed |
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
title_sort |
causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study |
publisher |
Taylor & Francis |
publishDate |
2021 |
url |
https://dx.doi.org/10.6084/m9.figshare.16960909.v1 https://tandf.figshare.com/articles/journal_contribution/Causes_of_gastrointestinal_bleeding_in_oral_anticoagulant_users_compared_to_non-users_in_a_population-based_study/16960909/1 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://dx.doi.org/10.1080/00365521.2021.1998600 https://dx.doi.org/10.6084/m9.figshare.16960909 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.16960909.v1 https://doi.org/10.1080/00365521.2021.1998600 https://doi.org/10.6084/m9.figshare.16960909 |
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