Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a w...
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2021
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ftdatacite:10.6084/m9.figshare.16657088 2023-05-15T14:31:07+02:00 Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness Tietgen, Lukas Hagen, Ingerid J. Kleven, Oddmund Bernardi, Cecilia Di Kvalnes, Thomas Norén, Karin Hasselgren, Malin Wallén, Johan Fredrik Angerbjörn, Anders Landa, Arild Eide, Nina E. Flagstad, Øystein Jensen, Henrik 2021 https://dx.doi.org/10.6084/m9.figshare.16657088 https://rs.figshare.com/articles/journal_contribution/Supplementary_material_1-7_9-12_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657088 unknown The Royal Society https://dx.doi.org/10.1098/rspb.2021.1452 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Genetics FOS Biological sciences Evolutionary Biology Ecology Text article-journal Journal contribution ScholarlyArticle 2021 ftdatacite https://doi.org/10.6084/m9.figshare.16657088 https://doi.org/10.1098/rspb.2021.1452 2021-11-05T12:55:41Z Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. Text Arctic Fox Arctic Vulpes lagopus DataCite Metadata Store (German National Library of Science and Technology) Arctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Genetics FOS Biological sciences Evolutionary Biology Ecology |
spellingShingle |
Genetics FOS Biological sciences Evolutionary Biology Ecology Tietgen, Lukas Hagen, Ingerid J. Kleven, Oddmund Bernardi, Cecilia Di Kvalnes, Thomas Norén, Karin Hasselgren, Malin Wallén, Johan Fredrik Angerbjörn, Anders Landa, Arild Eide, Nina E. Flagstad, Øystein Jensen, Henrik Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
topic_facet |
Genetics FOS Biological sciences Evolutionary Biology Ecology |
description |
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. |
format |
Text |
author |
Tietgen, Lukas Hagen, Ingerid J. Kleven, Oddmund Bernardi, Cecilia Di Kvalnes, Thomas Norén, Karin Hasselgren, Malin Wallén, Johan Fredrik Angerbjörn, Anders Landa, Arild Eide, Nina E. Flagstad, Øystein Jensen, Henrik |
author_facet |
Tietgen, Lukas Hagen, Ingerid J. Kleven, Oddmund Bernardi, Cecilia Di Kvalnes, Thomas Norén, Karin Hasselgren, Malin Wallén, Johan Fredrik Angerbjörn, Anders Landa, Arild Eide, Nina E. Flagstad, Øystein Jensen, Henrik |
author_sort |
Tietgen, Lukas |
title |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_short |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_fullStr |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full_unstemmed |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_sort |
supplementary material 1-7; 9-12 from fur colour in the arctic fox: genetic architecture and consequences for fitness |
publisher |
The Royal Society |
publishDate |
2021 |
url |
https://dx.doi.org/10.6084/m9.figshare.16657088 https://rs.figshare.com/articles/journal_contribution/Supplementary_material_1-7_9-12_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657088 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Vulpes lagopus |
genre_facet |
Arctic Fox Arctic Vulpes lagopus |
op_relation |
https://dx.doi.org/10.1098/rspb.2021.1452 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.16657088 https://doi.org/10.1098/rspb.2021.1452 |
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1766304837240094720 |