Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women
Impaired renal function is associated both with the development of cardiovascular disease and its prognosis. A new syndrome called ′Shrunken Pore Syndrome′ has been suggested, as the estimated glomerular filtration rate for cystatin C (eGFR cystatin C ) is affected earlier due to differences in mole...
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2021
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ftdatacite:10.6084/m9.figshare.14935834.v1 2023-05-15T17:44:58+02:00 Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women Söderström, Elisabet Blind, Ravna Wennberg, Patrik Andersson, Jonas Söderberg, Stefan Nilsson, Torbjörn K. Hultdin, Johan 2021 https://dx.doi.org/10.6084/m9.figshare.14935834.v1 https://tandf.figshare.com/articles/journal_contribution/Mild_impairment_of_renal_function_shrunken_pore_syndrome_is_associated_with_increased_risk_of_a_future_first-ever_myocardial_infarction_in_women/14935834/1 unknown Taylor & Francis https://dx.doi.org/10.1080/00365513.2021.1941235 https://dx.doi.org/10.6084/m9.figshare.14935834 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Marine Biology Cancer Science Policy Text article-journal Journal contribution ScholarlyArticle 2021 ftdatacite https://doi.org/10.6084/m9.figshare.14935834.v1 https://doi.org/10.1080/00365513.2021.1941235 https://doi.org/10.6084/m9.figshare.14935834 2021-11-05T12:55:41Z Impaired renal function is associated both with the development of cardiovascular disease and its prognosis. A new syndrome called ′Shrunken Pore Syndrome′ has been suggested, as the estimated glomerular filtration rate for cystatin C (eGFR cystatin C ) is affected earlier due to differences in molecular size compared to eGFR creatinine . The aim was to investigate if a lower eGFR cystatin C /eGFR creatinine ratio in a prospective setting increases the risk of later developing a first-ever myocardial infarction (MI) independently of other cardiovascular risk factors. We used a nested case-referent study design within the Northern Sweden Health and Disease Study, and 545 subjects (29.0% women) were identified who prospectively developed a first-ever MI, and their 1054 matched referents. For women, but not for men, one standard deviation (SD) increase of ln z -scores of eGFR cystatin C /eGFR creatinine ratio was associated with a lower risk of a future MI: odds ratio [95% confidence interval] 0.58 [0.34–0.99], adjusted for apolipoprotein B/A1 ratio, CRP, homocysteine, systolic blood pressure, body mass index, and diabetes. Furthermore, a high eGFR creatinine associated independently with an increased risk of future MI in men only: OR 1.25 [1.05–1.48]. Thus, for women, a lower eGFR cystatin C /eGFR creatinine ratio is associated with a higher risk of having a future first-ever MI, and it may be a valuable, easily implemented biomarker for risk of cardiovascular disease. Text Northern Sweden DataCite Metadata Store (German National Library of Science and Technology) |
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language |
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topic |
Medicine 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Marine Biology Cancer Science Policy |
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Medicine 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Marine Biology Cancer Science Policy Söderström, Elisabet Blind, Ravna Wennberg, Patrik Andersson, Jonas Söderberg, Stefan Nilsson, Torbjörn K. Hultdin, Johan Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
topic_facet |
Medicine 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences 69999 Biological Sciences not elsewhere classified FOS Biological sciences Marine Biology Cancer Science Policy |
description |
Impaired renal function is associated both with the development of cardiovascular disease and its prognosis. A new syndrome called ′Shrunken Pore Syndrome′ has been suggested, as the estimated glomerular filtration rate for cystatin C (eGFR cystatin C ) is affected earlier due to differences in molecular size compared to eGFR creatinine . The aim was to investigate if a lower eGFR cystatin C /eGFR creatinine ratio in a prospective setting increases the risk of later developing a first-ever myocardial infarction (MI) independently of other cardiovascular risk factors. We used a nested case-referent study design within the Northern Sweden Health and Disease Study, and 545 subjects (29.0% women) were identified who prospectively developed a first-ever MI, and their 1054 matched referents. For women, but not for men, one standard deviation (SD) increase of ln z -scores of eGFR cystatin C /eGFR creatinine ratio was associated with a lower risk of a future MI: odds ratio [95% confidence interval] 0.58 [0.34–0.99], adjusted for apolipoprotein B/A1 ratio, CRP, homocysteine, systolic blood pressure, body mass index, and diabetes. Furthermore, a high eGFR creatinine associated independently with an increased risk of future MI in men only: OR 1.25 [1.05–1.48]. Thus, for women, a lower eGFR cystatin C /eGFR creatinine ratio is associated with a higher risk of having a future first-ever MI, and it may be a valuable, easily implemented biomarker for risk of cardiovascular disease. |
format |
Text |
author |
Söderström, Elisabet Blind, Ravna Wennberg, Patrik Andersson, Jonas Söderberg, Stefan Nilsson, Torbjörn K. Hultdin, Johan |
author_facet |
Söderström, Elisabet Blind, Ravna Wennberg, Patrik Andersson, Jonas Söderberg, Stefan Nilsson, Torbjörn K. Hultdin, Johan |
author_sort |
Söderström, Elisabet |
title |
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
title_short |
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
title_full |
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
title_fullStr |
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
title_full_unstemmed |
Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
title_sort |
mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
publisher |
Taylor & Francis |
publishDate |
2021 |
url |
https://dx.doi.org/10.6084/m9.figshare.14935834.v1 https://tandf.figshare.com/articles/journal_contribution/Mild_impairment_of_renal_function_shrunken_pore_syndrome_is_associated_with_increased_risk_of_a_future_first-ever_myocardial_infarction_in_women/14935834/1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://dx.doi.org/10.1080/00365513.2021.1941235 https://dx.doi.org/10.6084/m9.figshare.14935834 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.14935834.v1 https://doi.org/10.1080/00365513.2021.1941235 https://doi.org/10.6084/m9.figshare.14935834 |
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1766147663743418368 |