Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes
Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three D...
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ftdatacite:10.6084/m9.figshare.14318656.v1 2023-05-15T14:02:06+02:00 Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes JI, Wei Chaohua ZHANG SONG, Cai Hongwu JI 2021 https://dx.doi.org/10.6084/m9.figshare.14318656.v1 https://scielo.figshare.com/articles/dataset/Three_DPP-IV_inhibitory_peptides_from_Antarctic_krill_protein_hydrolysate_improve_glucose_levels_in_the_zebrafish_model_of_diabetes/14318656/1 unknown SciELO journals https://dx.doi.org/10.1590/fst.58920 https://dx.doi.org/10.6084/m9.figshare.14318656 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY 90899 Food Sciences not elsewhere classified FOS Other engineering and technologies dataset Dataset 2021 ftdatacite https://doi.org/10.6084/m9.figshare.14318656.v1 https://doi.org/10.1590/fst.58920 https://doi.org/10.6084/m9.figshare.14318656 2021-11-05T12:55:41Z Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three DPP-IV inhibitory peptides activity. Physiochemical indexes including DPP-IV activity, glucose, triglyceride and cholesterol; the relative gene (insa, glucagon and pck1) expressions levels were detected. The results showed that after 15 days of peptides treatment, the physiochemical index levels of peptide groups were significantly higher than that of negative control and showed dose-dependent effect. The insa gene expression level would be increased with the enhancement of peptide concentration, whereas gene expression levels of glucagon and pck1 would be decreased. These results indicated that three peptides all had hypoglycemic effects in different degree. It suggested the potential of AKH containing DPP-IV inhibitory peptides could be as functional food supplement to treat diabetes. Dataset Antarc* Antarctic Antarctic Krill DataCite Metadata Store (German National Library of Science and Technology) Antarctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
90899 Food Sciences not elsewhere classified FOS Other engineering and technologies |
spellingShingle |
90899 Food Sciences not elsewhere classified FOS Other engineering and technologies JI, Wei Chaohua ZHANG SONG, Cai Hongwu JI Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
topic_facet |
90899 Food Sciences not elsewhere classified FOS Other engineering and technologies |
description |
Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three DPP-IV inhibitory peptides activity. Physiochemical indexes including DPP-IV activity, glucose, triglyceride and cholesterol; the relative gene (insa, glucagon and pck1) expressions levels were detected. The results showed that after 15 days of peptides treatment, the physiochemical index levels of peptide groups were significantly higher than that of negative control and showed dose-dependent effect. The insa gene expression level would be increased with the enhancement of peptide concentration, whereas gene expression levels of glucagon and pck1 would be decreased. These results indicated that three peptides all had hypoglycemic effects in different degree. It suggested the potential of AKH containing DPP-IV inhibitory peptides could be as functional food supplement to treat diabetes. |
format |
Dataset |
author |
JI, Wei Chaohua ZHANG SONG, Cai Hongwu JI |
author_facet |
JI, Wei Chaohua ZHANG SONG, Cai Hongwu JI |
author_sort |
JI, Wei |
title |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_short |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_full |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_fullStr |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_full_unstemmed |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_sort |
three dpp-iv inhibitory peptides from antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
publisher |
SciELO journals |
publishDate |
2021 |
url |
https://dx.doi.org/10.6084/m9.figshare.14318656.v1 https://scielo.figshare.com/articles/dataset/Three_DPP-IV_inhibitory_peptides_from_Antarctic_krill_protein_hydrolysate_improve_glucose_levels_in_the_zebrafish_model_of_diabetes/14318656/1 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_relation |
https://dx.doi.org/10.1590/fst.58920 https://dx.doi.org/10.6084/m9.figshare.14318656 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.14318656.v1 https://doi.org/10.1590/fst.58920 https://doi.org/10.6084/m9.figshare.14318656 |
_version_ |
1766272192791707648 |