A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease
The emergence of SARS-CoV-2, a coronavirus with suspected bat origins, highlights a critical need for heightened understanding of the mechanisms by which bats maintain potentially zoonotic viruses at the population level and transmit these pathogens across species. We review mechanistic models, whic...
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ftdatacite:10.6084/m9.figshare.13234292.v1 2023-05-15T13:41:34+02:00 A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease Gentles, Anecia D. Guth, Sarah Rozins, Carly Brook, Cara E. 2020 https://dx.doi.org/10.6084/m9.figshare.13234292.v1 https://tandf.figshare.com/articles/dataset/A_review_of_mechanistic_models_of_viral_dynamics_in_bat_reservoirs_for_zoonotic_disease/13234292/1 unknown Taylor & Francis https://dx.doi.org/10.1080/20477724.2020.1833161 https://dx.doi.org/10.6084/m9.figshare.13234292 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Medicine Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Science Policy 110309 Infectious Diseases FOS Health sciences 60506 Virology Dataset dataset 2020 ftdatacite https://doi.org/10.6084/m9.figshare.13234292.v1 https://doi.org/10.1080/20477724.2020.1833161 https://doi.org/10.6084/m9.figshare.13234292 2022-02-09T12:43:26Z The emergence of SARS-CoV-2, a coronavirus with suspected bat origins, highlights a critical need for heightened understanding of the mechanisms by which bats maintain potentially zoonotic viruses at the population level and transmit these pathogens across species. We review mechanistic models, which test hypotheses of the transmission dynamics that underpin viral maintenance in bat systems. A search of the literature identified only twenty-five mechanistic models of bat-virus systems published to date, derived from twenty-three original studies. Most models focused on rabies and related lyssaviruses (eleven), followed by Ebola-like filoviruses (seven), Hendra and Nipah-like henipaviruses (five), and coronaviruses (two). The vast majority of studies has modelled bat virus transmission dynamics at the population level, though a few nested within-host models of viral pathogenesis in population-level frameworks, and one study focused on purely within-host dynamics. Population-level studies described bat virus systems from every continent but Antarctica, though most were concentrated in North America and Africa; indeed, only one simulation model with no associated data was derived from an Asian bat-virus system. In fact, of the twenty-five models identified, only ten population-level models were fitted to data – emphasizing an overall dearth of empirically derived epidemiological inference in bat virus systems. Within the data fitted subset, the vast majority of models were fitted to serological data only, highlighting extensive uncertainty in our understanding of the transmission status of a wild bat. Here, we discuss similarities and differences in the approach and findings of previously published bat virus models and make recommendations for improvement in future work. Dataset Antarc* Antarctica DataCite Metadata Store (German National Library of Science and Technology) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
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unknown |
topic |
Medicine Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Science Policy 110309 Infectious Diseases FOS Health sciences 60506 Virology |
spellingShingle |
Medicine Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Science Policy 110309 Infectious Diseases FOS Health sciences 60506 Virology Gentles, Anecia D. Guth, Sarah Rozins, Carly Brook, Cara E. A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
topic_facet |
Medicine Ecology FOS Biological sciences 69999 Biological Sciences not elsewhere classified Science Policy 110309 Infectious Diseases FOS Health sciences 60506 Virology |
description |
The emergence of SARS-CoV-2, a coronavirus with suspected bat origins, highlights a critical need for heightened understanding of the mechanisms by which bats maintain potentially zoonotic viruses at the population level and transmit these pathogens across species. We review mechanistic models, which test hypotheses of the transmission dynamics that underpin viral maintenance in bat systems. A search of the literature identified only twenty-five mechanistic models of bat-virus systems published to date, derived from twenty-three original studies. Most models focused on rabies and related lyssaviruses (eleven), followed by Ebola-like filoviruses (seven), Hendra and Nipah-like henipaviruses (five), and coronaviruses (two). The vast majority of studies has modelled bat virus transmission dynamics at the population level, though a few nested within-host models of viral pathogenesis in population-level frameworks, and one study focused on purely within-host dynamics. Population-level studies described bat virus systems from every continent but Antarctica, though most were concentrated in North America and Africa; indeed, only one simulation model with no associated data was derived from an Asian bat-virus system. In fact, of the twenty-five models identified, only ten population-level models were fitted to data – emphasizing an overall dearth of empirically derived epidemiological inference in bat virus systems. Within the data fitted subset, the vast majority of models were fitted to serological data only, highlighting extensive uncertainty in our understanding of the transmission status of a wild bat. Here, we discuss similarities and differences in the approach and findings of previously published bat virus models and make recommendations for improvement in future work. |
format |
Dataset |
author |
Gentles, Anecia D. Guth, Sarah Rozins, Carly Brook, Cara E. |
author_facet |
Gentles, Anecia D. Guth, Sarah Rozins, Carly Brook, Cara E. |
author_sort |
Gentles, Anecia D. |
title |
A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
title_short |
A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
title_full |
A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
title_fullStr |
A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
title_full_unstemmed |
A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
title_sort |
review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease |
publisher |
Taylor & Francis |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.13234292.v1 https://tandf.figshare.com/articles/dataset/A_review_of_mechanistic_models_of_viral_dynamics_in_bat_reservoirs_for_zoonotic_disease/13234292/1 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://dx.doi.org/10.1080/20477724.2020.1833161 https://dx.doi.org/10.6084/m9.figshare.13234292 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.13234292.v1 https://doi.org/10.1080/20477724.2020.1833161 https://doi.org/10.6084/m9.figshare.13234292 |
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